Quality of life in patients with Behcet's disease and Recurrent aphthous stomatitis

Tu�rul Ayano�lu, Burcu; G�rler, Aysel; Erdo�an, Fatma G�lru; G�nd�z, �zge; Alhan, Asl�han

Quality of life in patients with Behcet's disease and Recurrent aphthous stomatitis [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2015; 49(4): 276-284 | DOI: 10.4274/turkderm.00868

Quality of life in patients with Behcet's disease and Recurrent aphthous stomatitis

Burcu Tu�rul Ayano�lu¹, Aysel G�rler², Fatma G�lru Erdo�an², �zge G�nd�z², Asl�han Alhan³
¹Aksaray State Hospital, Department of Dermatology and Venerology, Aksaray, Turkey
²Ufuk University School of Medicine, Department of Dermatology and Venerology
³Ufuk University Faculty of Arts And Sciences, Department of Statistics, Ankara, Turkey

Background and Design: Beh�et�s disease (BD) is an important cause of morbidity and mortality. Recurrent aphthous stomatitis (RAS) is a condition affecting oral health-related quality of life (QoL). In this study, we aimed to evaluate QoL of BD patients by using the Beh�et�s disease quality of life instrument (BDQLI) and to compare the QoL of patients with BD with that of patients with RAS and healthy controls.
Materials and Methods: Forty patients with BD and 40 patients with RAS and 40 healthy subjects with similar sociodemographic characteristics were included in the study. We used the BDQLI to evaluate QoL of patients with BD and the Dermatology-specific quality of life instrument for comparison of QqL between patients with BD and RAS. 36-Item Short Form Health Survey and clinical data form were applied in all participants. The results were analyzed statistically. The power of the study was 99%.
Results: QoL of patients with BD were lower than that of healthy controls. It was observed that patients with BD had decreased physical functions, impaired perception of pain and poor general health (p<0.001, p=0.001, p=0.016, <0.001). Physical functions were decreased and perception of general heath was worse in patients with RAS compared to healthy controls (p=0.018, p=0.021). There was no difference in QoL between patients with BD and RAS (p>0.05). Female gender, relapse periods and mucocutaneous symptoms negatively affected QoL of patients with BD. Female gender and duration of the disease were found to be the main factors affecting QoL of patients with RAS.
Conclusion: Unlike the results obtained with other instruments, with BDQLI, QoL, particularly in patients with active period and female gender was found to be decreased. In this study, there was a dominance of active mucocutaneous symptoms. This may explain the effect of mucocutaneous symptoms on QoL and the fact that there was no difference in QoL between BD and RAS patients. Further studies comparing QoL of patients with BD in whom visceral involvement is also observed with those with other diseases. QoL of BD patients may be improved by paying attention on symptoms that patients have trouble and by evaluating QoL with multidisciplinary approach during routine follow up.

Keywords: Behcet's disease, Recurrent aphtous stomatitis, quality of life, Beh�et�s disease quality of life instrument

Beh�et ve Rek�rren aft�z stomatit hastalar�nda ya�am kalitesi

Burcu Tu�rul Ayano�lu¹, Aysel G�rler², Fatma G�lru Erdo�an², �zge G�nd�z², Asl�han Alhan³
¹Aksaray Devlet Hastanesi, Deri ve Z�hrevi Hastal�klar Klini�i, Aksaray, T�rkiye
²Ufuk �niversitesi T�p Fak�ltesi, Deri ve Z�hrevi Hastal�klar
³Ufuk �niversitesi Fen Edebiyat Fak�ltesi, �statistik Anabilim Dal�, Ankara, T�rkiye

Ama�: Beh�et hastal��, ya�am kalitesini etkileyen �nemli morbidite ve mortalite sebebidir. Rek�rren aft�z stomatit (RAS) ise hastalar�n oral sa�l�kla ili�kili ya�am kalitelerinin bozuldu�u bir patolojidir. �al��mada, Beh�et hastalar�n�n ya�am kaliteleri hastal��a �zg� bir �l�ek olan Beh�et Hastal�� Ya�am Kalite �l�e�i (BYK�) de�erlendirilirken; RAS hastalar� ve sa�l�k kontrollerle ya�am kalitelerinin kar��la�t�r�lmas� ama�lanm��t�r.
Gere� ve Y�ntem: �al��maya 40 Beh�et hastas�, 40 RAS hastas� ve sosyo-demografik �zellikleri y�n�nden benzer 40 sa�l�kl� birey al�nd�. Beh�et hastalar�n�n ya�am kalitelerini kendi aras�nda de�erlendirme ama�l� BYK�, Beh�et ve RAS hasta gruplar�n�n ya�am kalitelerini kar��la�t�rma ama�l� Dermatolojik Ya�am Kalite indeksi uyguland�. T�m hasta ve kontrol grubuna K�sa Form-36 ile taraf�m�zdan haz�rlanan klinik bilgi veri formu uyguland�. Elde edilen veriler istatistiksel olarak de�erlendirildi. �al��man�n g�c� %99 olarak belirlendi.
Bulgular: Beh�et hastalar�n�n ya�am kaliteleri sa�l�kl� pop�lasyondan d��k bulundu. Beh�et hastalar�n�n fiziksel fonksiyon ve fiziksel fonksiyona ba�l� rol k�s�tl�l�klar� geli�tirdikleri; a�r�n�n ve sa�l��n genel alg�lanmas�nda s�k�nt� ya�ad�klar� izlendi (p<0,001, p=0,001, p=0,016 <0,001). RAS hastalar�n�n ise sa�l�kl� pop�lasyona g�re fiziksel fonksiyonlar�n�n ve sa�l�k alg�lar�n�n bozuldu�u tespit edildi (p=0,018, p=0,021). Beh�et ve RAS hastalar�n�n ya�am kalitelerinde fark olmad�� g�r�ld� (p>0,05). Beh�et hastalar�n�n ya�am kalitelerini, hastal��n aktif d�nemde olmas�n�n, kad�n cinsiyetin ve mukokutan�z bulgular�n negatif y�nde etkiledi�i g�r�ld�. RAS hastalar�n�n ya�am kalitelerini ise en �ok kad�n cinsiyet ve hastal�k s�resinin etkiledi�i izlendi.
Sonu�: BYK� ile di�er �l�eklerden farkl� olarak �zellikle aktif d�nemdeki ve kad�n cinsiyetteki Beh�et hastalar�nda ya�am kalitesindeki d��kl�k dikkat �ekmi�tir. �al��mada aktif mukokutan�z Beh�et hastalar�n�n bask�nl��, RAS hastalar�n�n ya�am kaliteleri ile fark olmamas�n� ve mukokutan�z bulgular�n ya�am kalitesi �zerindeki etkisini a��klayabilir. Aktif organ tutulumunun da g�r�ld��, Beh�et hastalar�n�n ya�am kaliteleri, di�er hastal�klarla kar��la�t�r�larak ileri �al��malarda de�erlendirilebilir. Beh�et hastalar�n rutin kontrollerinde, ya�am kalitelerinin de�erlendirilmesi ile s�k�nt� ya�ad�klar� semptomlara �nem verilmesi, multidisipliner yakla��mla tedaviye y�n verilmesi hastalar�n ya�am kalitesini olumlu y�nde artt�rabilir.

Anahtar Kelimeler: Beh�et hastal��, rek�rren aft�z stomatit, ya�am kalitesi, Beh�et hastal�� ya�am kalite �l�e�i

Burcu Tu�rul Ayano�lu, Aysel G�rler, Fatma G�lru Erdo�an, �zge G�nd�z, Asl�han Alhan. Quality of life in patients with Behcet's disease and Recurrent aphthous stomatitis. Turkderm-Turk Arch Dermatol Venereol. 2015; 49(4): 276-284

Corresponding Author: Burcu Tu�rul Ayano�lu, T�rkiye

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