Ocular Involvement in Behcet�s Disease

�zyazgan, Y�lmaz

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Ocular Involvement in Behcet�s Disease [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2009; 43(2): 48-53

Ocular Involvement in Behcet�s Disease

Y�lmaz �zyazgan

Uveitis secondary to systemic diseases and in particular to Beh�et�s disease is frequent in Turkey. Eye involvement is not confined to the uvea; it also involves the optic nerve and the retina due to the participation of the retinal vascular system. The clinical course is characterized by activations and remissions. Severity of eye involvement is heterogeneous among patients. The analysis of the frequency and severity of activations along with detection of sequel formation has prognostic significance. There is no specific medication for treatment of Beh�et�s disease. Local and systemic corticosteroids, immunosuppressives and immunomodulators are used and their side effects are monitored. Treatment end points are to decrease the frequency and severity of attacks and the prevention of sequelae.

Keywords: Beh�et�s disease, uveitis, frequency of activation, severity of activation, treatment

Beh�et Hastal��nda G�z Tutulumu

Y�lmaz �zyazgan
�stanbul �niversitesi Cerrahpa�a T�p Fak�ltesi, G�z Hastal�klar� Anabilim Dal�, �stanbul, T�rkiye

Sistemik hastal�klar beraberli�inde g�r�len �veitler aras�nda, �zellikle �lkemiz a��s�ndan, Beh�et hastal�� ili�kili �veitler kayda de�er bir oran� kapsamaktad�r. �veit, Beh�et hastal��nda major bulgular aras�nda de�erlendiriliyorsa da g�zdeki hastal��a ait belirtiler uvea dokusunda s�n�rl� kalmay�p retinal vask�ler sistem dolay�s�yla retina ve optik siniri de kapsamaktad�r. Klinik g�r�n�mde dikkat �eken �zelli�i zaman i�erisinde tekrarlayan aktivasyonlar g�stermesi ve sonras� sessiz d�nem ya�anmas�d�r. �G�z tutulumu �iddeti� ba�l�� alt�nda klinik g�r�n�m �zelliklerini tan�mlayan aktivasyon s�kl��, �iddeti ve g�z dokusundaki yap�sal hasar olu�umu hastalar aras�nda genelde farkl�l�k g�stermektedir. G�z tutulum �iddetini tan�mlayan unsurlar�n her olgu i�in analiz edilmesi, takip plan�, prognoz tayini ve tedavi etkinli�ini de�erlendirmede �nemli katk� sa�lamaktad�r. Beh�et hastal�� tedavisinde spesifik etkili ila�lar ve kan�tlanm�� y�ntem yoktur. Kortikosteroidler lokal ve sistemik olarak uzun y�llard�r kullan�lmaktad�r. �mm�nos�pressif, imm�nomod�lat�r ve �zellikle son y�llarda biyolojik etkili ila�lar, olu�abilecek yan etkiler g�z �n�nde bulundurularak, kontroll� olarak kullan�lmaktad�r.

Anahtar Kelimeler: Beh�et hastal��, �veit, aktivasyon s�kl��, aktivasyon �iddeti, tedavi

Y�lmaz �zyazgan. Ocular Involvement in Behcet�s Disease. Turkderm-Turk Arch Dermatol Venereol. 2009; 43(2): 48-53

Corresponding Author: Y�lmaz �zyazgan, T�rkiye

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