Kaposi�s sarcoma in renal transplantation patients:  clinical features and presence of human herpesvirus-8

Saray, Yasemin; Se�kin, Deniz; Butros, Reha; Haberal, Mehmet

Kaposi�s sarcoma in renal transplantation patients: clinical features and presence of human herpesvirus-8 [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2005; 39(4): 249-253

Kaposi�s sarcoma in renal transplantation patients: clinical features and presence of human herpesvirus-8

Yasemin Saray¹, Deniz Se�kin¹, Reha Butros², Mehmet Haberal³
¹Ba�kent �niversitesi T�p Fak�ltesi Dermatoloji Anabilim Dal�
²Ba�kent �niversitesi T�p Fak�ltesi D�nem VI ��rencisi
³Ba�kent �niversitesi T�p Fak�ltesi Genel Cerrahi Anabilim Dal�

Background and Design: The frequency of Kaposi�s sarcoma is increased in renal transplantation patients. The prevalence, clinical features and the etiopathological role of human herpesvirus-8 in Kaposi�s sarcoma in renal transplantation patients were investigated in this study.
Patients and METHODS: Files of renal transplantation patients who were diagnosed as Kaposi�s sarcoma have been examined. Human herpesvirus-8 DNA was investigated in the lesional skin of 6 patients.
RESULTS: The prevalence of Kaposi�s sarcoma was 1.2%. Mucocutaneous and visceral involvement was noted in 76.9% and 61.5% of the patients, respectively. In 61.5% of the patients total remission, in 23.1% partial remission was observed. Twent-five percent of the patients with visceral involvement were died. Viral DNA was detected in all of the 6 patients.
CONCLUSION: Visceral involvement is common in Kaposi�s sarcoma developing in renal transplant recipients and increases the mortality. Immunosuppresion with human herpesvirus-8 play roles in etiopathogenesis.

Keywords: Kaposi�s sarcoma, immunosuppression, transplantation

Renal Transplantasyon Hastalar�nda Kaposi Sarkomu: Klinik �zellikler ve �nsan Herpes Virusu-8�in Varl��

Yasemin Saray¹, Deniz Se�kin¹, Reha Butros², Mehmet Haberal³
¹Ba�kent �niversitesi T�p Fak�ltesi Deri ve Z�hrevi Hastal�klar Anabilim Dal�
²Ba�kent �niversitesi T�p Fak�ltesi D�nem VI ��rencisi
³Ba�kent �niversitesi T�p Fak�ltesi Genel Cerrahi Anabilim Dal�

Renal transplantasyon hastalar�nda Kaposi sarkomu s�kl�� artm��t�r. Bu �al��mada, renal transplantasyon hastalar�nda geli�en Kaposi sarkomunun prevelans�, klinik �zellikleri ile insan herpesvirusu-8�in etyolojideki rol� ara�t�r�ld�. Kaposi sarkomu tan�s� alan renal transplantasyon hastalan�n dosyalar� incelendi. Alt� hastada lezyonlu deride insan herpesvirusu-8 DNA�s� ara�t�r�ld�. Kaposi sarkomu prevelans� %1.2 idi. Mukok�tan�z tutulum %76.9�unda, viseral tutulum %61.5�inde saptanm��t�. Tedavi ile hastalar�n %61.5�inde remisyon, %23.1�inde parsiyel remisyon izlenmi�ti. Viseral tutulum olanlar�n %25�i �l�mle sonu�lanm��t�. Alt� hastan�n t�m�nde virusa ait DNA saptand�. Renal transplantasyon hastalar�nda geli�en Kaposi sarkomunda viseral tutulum s�kt�r ve mortaliteyi artt�r�r. Etyopatogenezde, imm�nos�presyon ile birlikte insan herpesvirusu-8 rol oynamaktad�r.

Anahtar Kelimeler: Kaposi sarkomu, imm�nos�presyon, transplantasyon

Yasemin Saray, Deniz Se�kin, Reha Butros, Mehmet Haberal. Kaposi�s sarcoma in renal transplantation patients: clinical features and presence of human herpesvirus-8. Turkderm-Turk Arch Dermatol Venereol. 2005; 39(4): 249-253

Corresponding Author: Yasemin Saray, T�rkiye

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