HLA antigens in basal cell carcinoma patients

Ko�, Melek Kesir; Onsun, Nahide; Kural, Yasemin Balsever; O�uz, Fatma Savran

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HLA antigens in basal cell carcinoma patients [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2004; 38(4): 271-276

HLA antigens in basal cell carcinoma patients

Melek Kesir Ko�¹, Nahide Onsun², Yasemin Balsever Kural³, Fatma Savran O�uz⁴
¹Ssk G�ztepe E�itim Hastanesi Dermatoloji Klini�i
²S.s.k. Vak�f Gureba E�itim Hastanesi Dermatoloji Klini�i
³Ssk Vak�f Gureba E�itim Hastanesi Dermatoloji Klini�i
⁴�stanbul �niversitesi �stanbul T�p Fak�ltesi T�bbi Biyoloji Anabilim Dal�

Basal cell carcinoma (BCC), is a malign skin tumor which originates from pluripotential cells of the basal cell layer and it is most frequently seen among caucasians. The etiology of BCC has not been able to completely known. In the previous studies, a probable correlation especially between BCC and HLA-DR groups were mentioned. In a BCC series consisted of 40 patents HLA grups was investigated to determine any such relation
between BCC and HLA in Turkish people. A control group consisted of 63 healthy individuals, with no blood relation, was used. HLA-A and HLA-B antigens were determined by Terasaki microlymphocytotoxicity method and HLA-DR antigens were determined by conducting to type at DNA level through with PCR- SSP � low resolution�. In our study which investigates the correlation between BCC and HLA antigens, we found a positive correlation between BCC and HLA-DR antigens, coherent with previous findings. We also found that there might be a positive correlation between HLA-A and HLA-B antigens.

Keywords: Basal cell carcinoma, HLA antigens

Bazal H�creli Karsinom Hastalar�nda HLA Antijenleri

Melek Kesir Ko�¹, Nahide Onsun², Yasemin Balsever Kural³, Fatma Savran O�uz⁴
¹Ssk G�ztepe E�itim Hastanesi Deri ve Z�hrevi Hastal�klar Klini�i
²S.s.k. Vak�f Gureba E�itim Hastanesi Deri ve Z�hrevi Hastal�klar Klini�i
³Ssk Vak�f Gureba E�itim Hastanesi Deri ve Z�hrevi Hastal�klar Klini�i
⁴�stanbul �niversitesi �stanbul T�p Fak�ltesi T�bbi Biyoloji Anabilim Dal�

Bazal h�creli karsinom (BHK), orijinini bazal h�cre tabakas�n�n pluripotansiyel primordial h�crelerinden alan, �zellikle beyaz tenli insanlarda en s�k g�r�len, derinin malin t�m�r�d�r. BHK�un etyolojisi tam olarak bilinmemektedir.
Daha �nce yap�lan �al��malarda �zellikle BHK ile HLA-DR grubu aras�nda ili�ki olabilece�i lehinde sonu�lar al�nm��t�r. T�rkiye�de bu y�nde yap�lm�� herhangi bir �al��ma olmad�� i�in biz kendi pop�lasyonumuzda BHK ile HLA aras�nda bir ili�ki olup olmad��n� ara�t�rd�k. Histopatolojik olarak BHK tan�s� konulan 40 olguda HLA gruplar� ara�t�r�ld�. Sa�l�kl� ve akrabal�k ili�kisi olmayan 63 kifli kontrol grubu olarak de�erlendirildi.
HLA-A ve HLA-B antijenleri Terasaki mikrolenfositotoksisite y�ntemi ile HLA-DR ise PCR-SSP ��low resolution�� ile DNA d�zeyinde tipleme yap�larak belirlendi.
�al��mam�zda bu konuda yap�lanlar ile uyumlu olarak BHK ile HLA-DR antijenleri aras�nda pozitif bir ili�ki saptand�. Ayr�ca HLA-A ve HLA-B antijenleri ile de pozitif bir ili�ki olabilece�i y�n�nde bulgular tespit edildi.

Anahtar Kelimeler: Bazal h�creli karsinom, HLA antijenleri

Melek Kesir Ko�, Nahide Onsun, Yasemin Balsever Kural, Fatma Savran O�uz. HLA antigens in basal cell carcinoma patients. Turkderm-Turk Arch Dermatol Venereol. 2004; 38(4): 271-276

Corresponding Author: Melek Kesir Ko�, T�rkiye

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