E-ISSN 2651-5164 / Print-ISSN 2717-6398
TURKDERM - Turkish Archives of Dermatology and Venereology - Turkderm-Turk Arch Dermatol Venereol: 58 (3)
Volume: 58  Issue: 3 - 2024
1. Cover

Pages I - V

ORIGINAL INVESTIGATION
2. Correlation of clinical, dermoscopic, and histopathological features of basal cell carcinoma
Didem Dizman, Dilek Bıyık Özkaya, Anıl Gülsel Bahali, Buğçe Topukçu Dizman, Pelin Yıldız, Zeynep Tosuner, Cüyan Demirkesen, Nahide Onsun, Özlem Su
doi: 10.4274/turkderm.galenos.2024.67915  Pages 54 - 65
Background and Design: The aim of this study is to enhance the diagnosis and treatment of basal cell carcinoma (BCC) by comparing clinical, dermoscopic, and pathological features.
Materials and Methods: This retrospective study included patients from the dermatology clinic between 2012 and 2015 with 111 BCC lesions.
Results: The average age for aggressive-type BCC patients was higher. Aggressive-type BCCs were more common on the face. Dermoscopic, gray-blue ovoid nests were more common on the trunk. Pigmented dots were less common on the face, while globules were more frequent on the scalp. Small erosions were more prevalent on the extremities, while shiny white-red structureless areas were more common on the trunk and extremities. Dot vessels were more prevalent on the scalp. Vascular features were more common on the face, whereas pigmented characteristics were less common. Other dermoscopic features were more common on the face and trunk. Arborizing vessels, ulcerations, white crystals, and hairpin vessels were more common in nodular lesions. Other dermoscopic features were more prevalent in nodular lesions. Mixed-type BCCs had more gray-blue ovoid nests and globules, while single-type BCCs had more small erosions. Vascular features were more common in mixed-type BCCs. Ulceration was more common in aggressive BCCs, while small erosions were more prevalent in nonaggressive BCCs. Histopathologically, pigmented BCCs were more common on the scalp and trunk than on the face. Superficial BCCs were more common in trunks and flat lesions. Adenoid BCC was more prevalent in nodular lesions. Scalp mixed-type BCCs were more common and aggressive. Mixed-type BCCs had a higher number of subtypes, including pigmented, infiltrative, adenoid, micronodular, and solid BCCs. Cystic degeneration was more common in mixed-type BCCs.
Conclusion: Clinical-pathological correlations and dermoscopic findings improve our understanding of BCC, aiding in accurate diagnosis and management.

3. Evaluation of clinical and follow-up outcomes in primary cutaneous B-cell lymphomas: A single-center retrospective study from 2006 to 2022
Hatice Şanlı, Handan Merve Erol Mart, Devrim Deniz Kuşçu, Işınsu Kuzu, Aylin Okçu Heper, Ayça Kırmızı, Bengü Nisa Akay
doi: 10.4274/turkderm.galenos.2024.08683  Pages 66 - 74
Background and Design: Primary cutaneous B-cell lymphomas (PCBCLs) have not been well characterized due to their relatively low incidence and heterogeneous clinical features.
Materials and Methods: Data of 29 patients with primary cutaneous marginal zone lymphoma (PCMZL) (n=18), primary cutaneous follicle center B-cell lymphoma (PCFCL) (n=7), and primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT) (n=4) who were followed and treated at Ankara University Faculty of Medicine between 2006 and 2022 were retrospectively evaluated. Clinical characteristics, treatment modalities, and outcomes of all patients were analyzed.
Results: Our study supports the data that there are geographical differences in the distribution of B-cell lymphomas and that PCMZL is predominant in Asian countries compared to Europe. The mean age at the time of diagnosis in the PCDLBCL-LT group was significantly older than the indolent PCBCL group (p=0.022). The lesion size was predominantly less than 2 cm in PCMZL, between 2 and 5 cm in PCFCL, and larger than 5 cm in the PCDLBCL-LT group (p=0.006). While skin-directed treatments were the most common approach in the PCMZL and PCFCL groups, multi-agent chemotherapy was the preferred treatment in the PCDLBCL-LT group (p=0.003 and p=0.001, respectively). No significant correlation was found between age, gender, clinical features of the lesion, cutaneous lymphoma international prognostic index score, stage and treatment modalities, recurrence, and overall survival. The World Health Organization and European Organization for Research and Treatment of Cancer classification of cutaneous lymphoma remains the primary guideline for understanding the clinical behavior and prognostic parameters of this heterogeneous patient group.
Conclusion: Given the relative rarity of these types of lymphoma, our patient collective provides an additional value to the existing literature.

4. Relationship between Glutathione S-transferase gene polymorphisms and clinical features of psoriasis: A case-control study in the Turkish population
Hatice Gül Dursun, Recep Dursun, ilknur Çınar Ayan, Ayşe Gül Zamani, Mahmur Selman Yıldırım
doi: 10.4274/turkderm.galenos.2024.83641  Pages 75 - 82
Background and Design: In this study, we investigated whether Glutathione S-transferase Mu 1 (GSTM1) and Glutathione S-transferase Pi 1 (GSTP1) gene polymorphisms are risk factors for psoriasis development and characteristics of psoriasis.
Materials and Methods: Venous blood samples were collected from both the patients and control subjects into 2 mL EDTA tubes. DNA was isolated from 260 psoriasis patients and 200 healthy control subjects, and GSTM1 and GSTP1 gene polymorphisms were genotyped by realtime polymerase chain reaction method.
Results: According to the analysis results, although the frequency of the GSTM1 null genotype was 1.33 times higher in patients compared to controls, this difference was statistically insignificant [95% confidence interval (CI): 0.91-1.93, p=0.13]. GSTP1 AG heterozygous genotype and GG homozygous polymorphic genotype frequencies also did not differ between patients and controls [odds ratio (OR): 0.80, 95% CI: 0.55-1.18, p=0.27 for AG genotype; OR: 0.74, 95% CI: 0.35-1.56, p=0.42 for GG genotype]. When both polymorphisms were evaluated based on the onset age and severity of the disease, no significant difference was found between the early onset age group and the late onset age group, nor between the mild group and the severe group.
Conclusion: The results show that GSTM1 and GSTP1 polymorphisms do not have a major effect on the etiopathogenesis and clinical characteristics of psoriasis.

CASE REPORT
5. Four cases, one syndrome: Gardner-Diamond syndrome
Ebrar Gültekin, Sıla Çavdar, N. Yasemin Ardıçoğlu Akışın, Şahika Baysun, Nejat Akar
doi: 10.4274/turkderm.galenos.2024.43410  Pages 83 - 86
Gardner-Diamond syndrome (GDS) is a condition characterized by the appearance of unexplained ecchymosis on the skin. Other common symptoms include gastrointestinal complaints, such as abdominal pain and vomiting, as well as complaints about the nervous and musculocutaneous systems. We typically diagnose GDS by ruling out other potential causes, as the exact cause remains unknown. Middle-aged women mostly suffer from this disease, which is believed to have a strong psychological component in its cause. Despite the limited number of documented cases of GDS globally, our goal is to showcase four confirmed cases of the disease.

LETTER TO THE EDITOR
6. Dissecting cellulitis of the scalp after hair transplantation: A case report
Aslı Bilgiç, Özlem Dicle, Cumhur İbrahim Başsorgun, Ayşe Akman
doi: 10.4274/turkderm.galenos.2024.01023  Pages 87 - 89
Abstract |Full Text PDF

WHAT IS YOUR DIAGNOSIS?
7. What is Your Diagnosis?
Sarenur Esener
doi: 10.4274/turkderm.galenos.2024.29895  Pages 90 - 91
Abstract |Full Text PDF

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