Evaluation of serum vitamin D levels in patients with lichen planus
Deniz Aksu Ar?ca1, Leyla Baykal Selçuk1, As?m Örem2, Zeynep Karaca Ural1, Sava? Yayl?1, Sevgi Bahad?r11Karadeniz Technical University Faculty of Medicine, Department of Dermatology and Venereology, Trabzon, Turkey2Karadeniz Technical University Faculty of Medicine, Department of Biochemistry, Trabzon, Turkey
Background and Design: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology that most commonly affects the skin and oral mucosa. Vitamin D is a steroid hormone with immunomodulatory, anti-inflammatory and antioxidant effects. The purpose of this study was to evaluate serum vitamin D levels in patients with LP and to compare these with those of healthy control subjects.
Materials and Methods: Forty-eight patients with a diagnosis of LP and 46 healthy controls were enrolled in the study. The serum levels of 25-hydroxy vitamin D, calcium, phosphate and parathyroid hormone were studied from blood samples collected from all subjects.
Results: The serum levels of vitamin D were lower in the LP patients compared to the controls and in the oral erosive LP patients compared to the other LP patients, although the difference was not statistically significant. There were no statistically significant differences in other laboratory parameters between the patient and the control groups.
Conclusion: Our study revealed no clear relation between LP and vitamin D levels. The results of our study suggest that other factors except vitamin D, particularly probable triggers, play a more dominant role in the immunopathogenesis of LP. Further studies with larger patient populations assessing serum vitamin D levels in different types of LP and vitamin D-related gene polymorphisms are now needed in order to reveal the relation between LP and Vitamin D more clearly.
Keywords: Lichen planus, vitamin D, etiology, oral lichen planus
Liken planus hastalar?nda serum vitamin D seviyelerinin de?erlendirilmesi
Deniz Aksu Ar?ca1, Leyla Baykal Selçuk1, As?m Örem2, Zeynep Karaca Ural1, Sava? Yayl?1, Sevgi Bahad?r11Karadeniz Teknik Üniversitesi T?p Fakültesi, Deri ve Zührevi Hastal?klar Anabilim Dal?, Trabzon2Karadeniz Teknik Üniversitesi T?p Fakültesi, Biyokimya Anabilim Dal?, Trabzon
Amaç: Liken planus (LP), etiyolojisi bilinmeyen, s?kl?kla deri ve oral mukozay? etkileyen, kronik enflamatuvar bir hastal?kt?r. D vitamini immünomodülatör, anti-enflamatuvar ve antioksidan etkileri olan bir steroid hormondur. Bu çal??man?n amac? LP tan?l? hastalarda serum D vitamin düzeylerini de?erlendirmek ve bunlar? sa?l?kl? kontrol grubuyla kar??la?t?rmakt?r.
Gereç ve Yöntem: Çal??maya LP tan?s? alm?? 46 hasta ve 46 sa?l?kl? kontrol al?nd?. Tüm olgulardan toplanan kan örneklerinden serum 25-hidroksi D vitamini, kalsiyum, fosfat ve paratiroid hormon düzeyleri çal???ld?.
Bulgular: Serum D vitamini düzeyleri LP’li hastalarda kontrollere göre ve oral erozif LP’li hastalarda di?er LP’li hastalara göre daha dü?ük bulundu, ancak fark istatistiksel olarak anlaml? de?ildi. Di?er laboratuvar parametrelerinde hasta ile kontrol grubu aras?nda istatistiksel olarak anlaml? fark yoktu.
Sonuç: Çal??mam?z LP ve D vitamini düzeyleri aras?nda net bir ili?ki olmad???n? ortaya koydu. Çal??mam?z?n bulgular?, D vitamini d???ndaki di?er faktörlerin, özellikle olas? tetikleyicilerin, LP’nin immünopatogenezinde daha bask?n bir rol oynayabilece?ini dü?ündürmektedir. LP ve D vitamini aras?ndaki ili?kiyi daha aç?k bir ?ekilde ortaya koymak için, farkl? LP türlerinde serum D vitamini düzeylerini ve D vitamini ile ili?kili gen polimorfizmlerini de?erlendiren daha geni? hasta popülasyonlar? ile ileri çal??malara ihtiyaç vard?r.
Anahtar Kelimeler: Liken planus, vitamin D, etiyoloji, oral liken planus
Manuscript Language: English