Reflectance Confocal M�croscopy; Morphology of Normal Skin and The Use in Melanocytic Lesions

Turgut Erdemir, Asl� Vefa; Koku Aksu, Ay�e Esra

Reflectance Confocal M�croscopy; Morphology of Normal Skin and The Use in Melanocytic Lesions [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2013; 47(3): 136-141 | DOI: 10.4274/turkderm.00907

Reflectance Confocal M�croscopy; Morphology of Normal Skin and The Use in Melanocytic Lesions

Asl� Vefa Turgut Erdemir, Ay�e Esra Koku Aksu
Istanbul Training And Research Hospital

In vivo reflectance confocal microscopy (RCM) is a noninvasive method that allows imaging of cells and structures in living skin with resolution close to the histological analysis. RCM allows the assessment of dynamic events in the epidermis, papillary dermis and superficial reticular dermis. From the stratum corneum to a depth of a maximum of 350 μm can be analysed. The noninvasive feature of this technique, allows repetitive imaging without any damage to the affected area and to evaluate the response to the treatment. RCM, provides great convenience in assesment of normal skin and particularly in the evaluation of melanocytic lesions due to high contrast features of melanin and melanosomes. In this article morphology of normal skin and features of melanocytic lesions is described with RCM.

Keywords: melanocytic skin lesions, reflectance confocal microscopy

Reflektans Konfokal Mikroskopi; Normal Deri Morfolojisi ve Melanositik Lezyonlarda Kullan�m�

Asl� Vefa Turgut Erdemir, Ay�e Esra Koku Aksu
�stanbul E�itim Ve Ara�t�rma Hastanesi,dermatoloji Klini�i

�n vivo Reflektans Konfokal Mikroskopi (RKM); canl� deride, h�cre ve di�er yap�lar�n histolojik analize yak�n d�zeyde g�r�nt�lenmesini sa�layan noninvaziv bir tan� y�ntemidir. Epidermis, papiller dermis ve y�zeyel retik�ler dermisdeki dinamik olaylar�n de�erlendirilmesine olanak sa�lar. Stratum korneumdan ba�layarak maksimum 350 μm derinli�e kadar incelenebilir. Bu y�ntemin noninvaziv �zelli�i, etkilenen alanda hasara yol a�madan tekrarlayan g�r�nt�leme yapma ve tedavi yan�t�n�n de�erlendirilmesine olanak sa�lar. RKM, melanin ve melanozomlar�n y�ksek kontrast kayna�� olmas� nedeni ile normal derinin ve �zellikle melanositik deri lezyonlar�n�n de�erlendirilmesinde b�y�k kolayl�klar sa�lamaktad�r. Bu makalede RKM ile normal deri morfolojisi ve melanositik lezyonlar�n�n �zellikleri anlat�lmaktad�r.

Anahtar Kelimeler: melanositik deri lezyonlar�, reflektans konfokal mikroskopi

Asl� Vefa Turgut Erdemir, Ay�e Esra Koku Aksu. Reflectance Confocal M�croscopy; Morphology of Normal Skin and The Use in Melanocytic Lesions. Turkderm-Turk Arch Dermatol Venereol. 2013; 47(3): 136-141

Corresponding Author: Asl� Vefa Turgut Erdemir, T�rkiye

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