Screening of antibiotic resistant Propionibacterium acnes from acne vulgaris patients:  Data from Pamukkale University.

Ergin, �a�r�; Ergin, �eniz; Kaleli, �lknur; �eng�l, Mustafa; �.Erdo�an, Berna

Screening of antibiotic resistant Propionibacterium acnes from acne vulgaris patients: Data from Pamukkale University. [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2007; 41(1): 19-21

Screening of antibiotic resistant Propionibacterium acnes from acne vulgaris patients: Data from Pamukkale University.

�a�r� Ergin¹, �eniz Ergin², �lknur Kaleli¹, Mustafa �eng�l¹, Berna �.Erdo�an²
¹Pamukkale University, Department of Microbiology, Denizli, Turkey
²Pamukkale University, Department of Dermatology, Denizli, Turkey

Background and Design: Antibiotic resistant Propionibacterium acnes is the main etiologic factor for failure of the acne therapy. In this study, the prevalance of antibiotic resistant P.acnes was investigated in our region. MATERIAL-METHOD: One hundred ninty-two acne vulgaris patients admitted to dermatology clinic were included in the study. Demographic and clinical data were recorded. Anaerobic culture was used for the samples collected by detergent scrub technique. Agar dilution technique was chosen for strains' antimicrobial susceptibilities. RESULTS: Propionibacterium acnes was isolated from 117 (60.9%) of 192 acne vulgaris patients. Antibiotic resistance of P.acnes was found in 10 (8.54%) strain. Erythromycin (9 strain), clindamycin (7 strain) and tetracycline (1 strain) resistance was found as 7.7%, 6.0% and 0.9%, respectively. Doxycyline resistance was not found. CONCLUSION: The prevalance of antibiotic resistant P.acnes is low and therapeutic failure is not expected due to resistant strains. Resistance rates of P.acnes may be detect via community surveillance programmes.

Keywords: Acne, Propionibacterium acnes, antibiotics, resistance

Akne vulgaris hastalar�nda antibiyotik diren�li Propionibacterium acnes varl��n�n ara�t�r�lmas�: Pamukkale �niversitesi verileri

�a�r� Ergin¹, �eniz Ergin², �lknur Kaleli¹, Mustafa �eng�l¹, Berna �.Erdo�an²
¹Pamukkale �niversitesi T�p Fak�ltesi, Mikrobiyoloji Ana Bilim Dal�, Denizli, T�rkiye
²Pamukkale �niversitesi T�p Fak�ltesi, Deri ve Z�hrevi Hastal�klar Ana Bilim Dal�, Denizli, T�rkiye

AMA�: Akne vulgaris tedavisinde tedavi ba�ar�s�zl��na yol a�an sorunlardan biri antibiyotik diren�li �Propionibacterium acnes�tir. Bu �al��mada b�lgemizde hastaneye ba�vuran akne vulgaris hastalar�nda �P.acnes� k�kenlerinde antibiyotik direnci varl�� ara�t�r�lm��t�r. GERE�-Y�NTEM: Hastaneye akne vulgaris �ikayeti ile ba�vuran hastalardan son 4 hafta i�inde antibiyotik kullan�m� olmayan 192 hasta �al��maya al�nd�. Bu hastalar�n demografik ve klinik �zellikleri kaydedildi. �rnekler deterjan f�r�alama tekni�i ile al�narak anaerobik ortamda k�lt�re edildi. K�kenlerin antibiyotik duyarl�l�k testleri agar dil�syon tekni�i ile yap�ld�. BULGULAR: �al��maya al�nan 192 hastan�n 117'sinden (%60.9) �P.acnes� k�keni izole edildi. �zole edilen �P.acnes� k�kenlerinden 10'unda (%8.5) antibiyotik direnci saptand�. Akne vulgaris etkeni olarak izole edilen �P.acnes� k�kenlerinde eritromisine (9 k�ken; %7.7), klindamisine (7 k�ken; %6.0), tetrasikline (1 k�ken; %0.9) diren� bulunurken, doksisikline kar�� diren� saptanmad�. YORUM: B�lgemizdeki hastalarda antibiyotik diren�li �P.acnes� klinik olarak tedavi ba�ar�s�zl�� yaratacak d�zeyde de�ildir. Diren� varl��n� taramak i�in toplum taramalar�n�n yap�lmas� �nemlidir.

Anahtar Kelimeler: Akne, Propionibacteterium acnes, anibiyotikler, diren�

�a�r� Ergin, �eniz Ergin, �lknur Kaleli, Mustafa �eng�l, Berna �.Erdo�an. Screening of antibiotic resistant Propionibacterium acnes from acne vulgaris patients: Data from Pamukkale University.. Turkderm-Turk Arch Dermatol Venereol. 2007; 41(1): 19-21

Corresponding Author: �a�r� Ergin, T�rkiye

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