Subcorneal pustular dermatosis �Sneddon-Wilkinson disease�: A case report

�ahin, Asl�; Edg�er, Emine Yal��n; Astarc�, Hesna M�zeyyen; Ek�io�lu, Hatice Meral

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Subcorneal pustular dermatosis �Sneddon-Wilkinson disease�: A case report [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2017; 51(1): 21-23 | DOI: 10.4274/turkderm.22755

Subcorneal pustular dermatosis �Sneddon-Wilkinson disease�: A case report

Asl� �ahin¹, Emine Yal��n Edg�er², Hesna M�zeyyen Astarc�³, Hatice Meral Ek�io�lu²
¹Abant Izzet Baysal University, Izzet Baysal Training And Investigation Hospital, Dermatology Department, Bolu
²Ankara Training And Investigation Hospital, Dermatology Department, Ankara
³Abant Izzet Baysal University Medical Faculty, Pathology Department, Bolu

Subcorneal pustular dermatosis (SPD), first described by Sneddon and Wilkinson in 1956, is rare, chronic, and relapsing dermatosis. Mostly, it affects women aged 40-50-years. It is characterized by grouped, annular, circinate, serpiginous, and sterile pustules on normal or erythematous ground. Lesions tend to involve intertriginous areas, the trunk, and extremities symmetrically. The etiology is not known; it has been suggested that it is a reactive neutrophilic dermatosis. In this report, we present a 71-year-old female who presented with lesions involving mostly intertriginous areas and received the clinical and histopathological diagnosis of SPD based on direct immunofluorescence assay. The patient was treated successfully with topical mupirocin 2% pomade, 1% blue de metylene, and oral macrolid 1 gr/day while being investigated for gammopathy and myeloproliferative diseases and waiting for biopsy results. After the biopsy results were obtained, the treatment of the patient continued with clobetasol 17-propionate 0.05%, colchium dispert 2x0.5 mg and dapsone 100 mg/day. The case was evaluated in the light of the relevant literature.

Keywords: Subcorneal pustular dermatosis, Sneddon-Wilkinson disease, neutrophilic dermatosis

Subkorneal p�st�ler dermatoz �Sneddon-Wilkinson hastal��: Bir olgu sunumu

Asl� �ahin¹, Emine Yal��n Edg�er², Hesna M�zeyyen Astarc�³, Hatice Meral Ek�io�lu²
¹Abant �zzet Baysal �niversitesi, �zzet Baysal E�itim Ve Ara�t�rma Hastanesi, Dermatoloji, Bolu
²Ankara E�itim Ve Ara�t�rma Hastanesi, Dermatoloji, Ankara
³Abant �zzet Baysal �niversitesi T�p Fak�ltesi, Patoloji Anabilim Dal�, Bolu

�lk kez 1956'da Sneddon ve Wilkinson taraf�ndan tan�mlanan subkorneal p�st�ler dermatoz (SPD), nadir, kronik, tekrarlay�c� seyirli bir dermatozdur. S�kl�kla kad�nlarda ve 40-50 ya�larda izlenir. Normal veya eritemli zeminde gruplar halinde ortaya ��kan, an�ler, sirsine, serpijin�z, steril p�st�llerle karakterizedir. Lezyonlar intertrijin�z alanlar, g�vde ve ekstremitelerde simetrik yerle�me e�ilimindedir. Etiyolojisi bilinmeyen hastal��n reaktif n�trofilik dermatoz oldu�u ileri s�r�lmektedir. Bu �al��mada, daha �ok intertrijin�z yerle�imli lezyonlar �ikayetiyle poliklini�imize ba�vuran; klinik, histopatoloji ve direkt imm�nfloresan inceleme sonucunda SPD tan�s� konan, gamapati ve miyeloproliferatif hastal�k y�n�nden tetkik edilip, biyopsi sonu�lar� beklenirken topikal mupirosin %2 merhem, %1 metilen mavisi ile 2x1 haricen boyama ve ampirik olarak oral makrolid 1 gr/g�n ile tedavi edilip, biyopsi sonucu sonras�nda %0,05 klobetazol-17 propiyonat, kol�isin 2x0,5 mg, dapson 100 mg/g�n ile tedaviye devam etti�imiz 71 ya��ndaki bir kad�n olgu literat�r bilgileri e�li�inde sunulmu�tur.

Anahtar Kelimeler: Subkorneal p�st�ler dermatoz, Sneddon-Wilkinson hastal��, n�trofilik dermatozlar

Asl� �ahin, Emine Yal��n Edg�er, Hesna M�zeyyen Astarc�, Hatice Meral Ek�io�lu. Subcorneal pustular dermatosis �Sneddon-Wilkinson disease�: A case report. Turkderm-Turk Arch Dermatol Venereol. 2017; 51(1): 21-23

Corresponding Author: Asl� �ahin, T�rkiye

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