Current Treatment Options in Challenging Oral Diseases: Recurrent Oral Aphthosis [Turkderm-Turk Arch Dermatol Venereol]
Turkderm-Turk Arch Dermatol Venereol. 2012; 46(2): 123-129 | DOI: 10.4274/turkderm.46.s2.22  

Current Treatment Options in Challenging Oral Diseases: Recurrent Oral Aphthosis

Zeynep Topkarcı
S. B. Bakirkoy Dr. Sadi Konuk Training And Research Hospital, Department Of Dermatology, Istanbul, Turkey

Recurrent oral aphthosis (ROA) is the most common cause of oral ulceration. The etiology is still not well understood, although local and systemic conditions, genetic, immunological and microbial factors play a role in the pathogenesis. The aim of the treatment is to control pain, accelerate the healing and prevent recurrences. The mainstay of treatment is topical therapy with anesthetics, antiseptics, anti-inflammatories, tetracyclines, sucralfate or steroids. Nevertheless, topical treatments may not always adequate or if there are major ulcers or persistent ulcers, systemic therapy is required. The main agents used in the treatment are systemic steroids, colchicine, pentoxifylline, thalidomide, dapsone, azathioprine, and methotrexate. In recent years, anti-TNF-alpha biological agents had been used for therapy and found to be effective.

Keywords: Recurrent, oral aphthosis, treatment

Zorlu Oral Hastalıklarda Güncel Tedavi: Rekürren Oral Aftozis

Zeynep Topkarcı
S. B. Bakırköy Dr. Sadi Konuk Eğitim Araştırma Hastanesi, Dermatoloji Kliniği, İstanbul, Türkiye

Rekürren oral aftozis (ROA) oral ülserasyonun en sık sebebidir. Etyolojisi henüz belli olmamakla birlikte, lokal ve sistemik koşullar ile genetik, immünolojik ve mikrobial faktörlerin hepsi patogenezde rol oynayabilir. Tedavide temel amaçlar; ağrı kontrolü, iyileşmeyi hızlandırmak ve tekrarları önlemektir. Tedavinin temelini anestezik, antiseptik, anti-inflamatuar, tetrasiklin, sukralfat veya steroidlerle topikal tedavi oluşturur. Topikal tedavilerle yeterli yanıt alınamadığı veya inatçı majör ülserlerde sistemik tedaviler gerekir. Sistemik tedavide kullanılan başlıca ajanlar; steroid, kolşisin, pentoksifilin, talidomid, dapson, azatioprin ve metotreksattır. Son yıllarda anti-TNF-alfa biyolojik ajanlar da tedavide kullanılmaya başlanmış ve etkili bulunmuştur.

Anahtar Kelimeler: Rekürren, oral aftozis, tedavi

Zeynep Topkarcı. Current Treatment Options in Challenging Oral Diseases: Recurrent Oral Aphthosis. Turkderm-Turk Arch Dermatol Venereol. 2012; 46(2): 123-129

Corresponding Author: Zeynep Topkarcı, Türkiye

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