Immunomodulators in Dermatology

Kumbasar, Eda; G�kdemir, Gonca; K��l�, Adem

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Immunomodulators in Dermatology [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2008; 42(1): 3-8

Immunomodulators in Dermatology

Eda Kumbasar, Gonca G�kdemir, Adem K��l�
�i�li Etfal E�itim Ve Ara�t�rma Hastanesi Dermatoloji Klini�i, �stanbul, Turkey

Immunomodulators include both immunostimulatory and immunosuppressive agents. The introduction of this new class of drugs marked the beginning of the post-cortisone era in clinical dermatology. Topical immunotherapy with both immunostimulatory and immunosuppressive agents show potential for effective treatment of inflammatory, infectious and neoplastic skin diseases. These agents have few side effects and have clinical effects similar to corticosteroids. The purpose of this review is to introduce to our collagues potentially useful immunomodulators in clinical

Keywords: �mmunomodulators, treatment, interferon, imiquimod, tacrolimus, pimecrolimus, alefacept, etanercept, infliximab, adalimumab, thalidomide, mycophenylate mofetil

Dermatolojide �mm�nmod�lat�rler

Eda Kumbasar, Gonca G�kdemir, Adem K��l�
�i�li Etfal E�itim Ve Ara�t�rma Hastanesi Deri ve Z�hrevi Hastal�klar Klini�i, �stanbul, T�rkiye

ajanlard�r. Bu yeni s�n�f ila�lar�n klinik dermatolojide kullan�ma girmesi �post-kortizon� �a��n ba�lam�� oldu�unu d��nd�rebilir. �lerleyen teknoloji ile birlikte herg�n yeni bir imm�nmodulat�r ajan geli�tirilmi�tir. Bu ajanlar kortikosteroidlerle benzer klinik etkilere sahip olup, yan etkileri olduk�a azd�r. Topikal ve sistemik imm�noterapi ajanlar� enflamatuar, enfeksiy�z ve neoplastik deri hastal�klar�nda giderek artan oranda kullan�lmaya ba�lanm��t�r. Bu derlemede dermatolojide kullan�labilecek imm�nmod�lat�rler literat�r bilgileri ��nda sunulmaktad�r.

Anahtar Kelimeler: mm�nmod�lat�rler, tedavi, interferon, imikuimod, takrolimus, pimekrolimus, alefasept, etanersept, infliksimab, adalimumab, talidomid, mikofenolat mofetil

Eda Kumbasar, Gonca G�kdemir, Adem K��l�. Immunomodulators in Dermatology. Turkderm-Turk Arch Dermatol Venereol. 2008; 42(1): 3-8

Corresponding Author: Eda Kumbasar, T�rkiye

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