Improvement in Attention and Executive Functions During Isotretinoin Treatment in Patients With Acne

Deveci, Erdem; �zt�rk, Ahmet; K�rp�nar, �smet; Engin, Rag�p �smail; Meliko�lu, Mehmet; Cafero�lu Sakat, Selcen; Demir, Muhammet; Canpolat, Serpil

Improvement in Attention and Executive Functions During Isotretinoin Treatment in Patients With Acne [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2013; 47(2): 109-113 | DOI: 10.4274/turkderm.93546

Improvement in Attention and Executive Functions During Isotretinoin Treatment in Patients With Acne

Erdem Deveci¹, Ahmet �zt�rk², �smet K�rp�nar¹, Rag�p �smail Engin³, Mehmet Meliko�lu³, Selcen Cafero�lu Sakat³, Muhammet Demir², Serpil Canpolat⁴
¹Bezmialem Vakif University, School Of Medicine, Department Of Psychiatry, Istanbul, Turkey
²Erzurum Regional Training And Research Hospital, Department Of Psychiatry, Erzurum, Turkey
³Erzurum Regional Training And Research Hospital, Department Of Dermatology, Erzurum, Turkey
⁴�umra State Hospital, Department Of Psychiatry, Konya, Turkey

Background and Design: We assessed attention, memory, verbal-linguistic ability, and executive functions in acne vulgaris patients before and during isotretinoin treatment.

Materials and Methods: Fifty-two treatment-naive acne patients at baseline and 24 at the second visit were evaluated. A neurocognitive battery including the Rey Auditory Verbal Learning and Memory Test, Auditory Consonant Trigram Test, Controlled Word Association Test, Digit Span Test, Trail Making Test A and B and the Stroop Test was used. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Hospital Anxiety and Depression Scale (HADS), and the Liebowitz Social Anxiety Scale (LSAS) were also applied.

Results: We found improvements in attention and executive functions at the second visit in comparison with the baseline evaluations. No alteration was found in verbal episodic memory, learning, working memory, and phonemic verbal fluency (Digit Span Forwards Test p=0.003, Trial Making-A Test p=0.002, Trial Making �B Test p=0.000, Stroop test p=0.028).

Discussion: The positive effects of isotretinoin on cognitive functions may be related to the decline in acne lesions and less mental occupation with the social impacts of acne.

Keywords: Acne, isotretinoin, neurocognitive functioning, memory, executive functions, attention, verbal fluency

Akneli Hastalarda �zotretinoin Kullan�m� S�ras�nda Dikkat ve Y�r�t�c� ��levlerde D�zelme

Erdem Deveci¹, Ahmet �zt�rk², �smet K�rp�nar¹, Rag�p �smail Engin³, Mehmet Meliko�lu³, Selcen Cafero�lu Sakat³, Muhammet Demir², Serpil Canpolat⁴
¹Bezmialem Vakif Universitesi T�p Fak�ltesi Psikiyatri Anabilim Dal�, �stanbul, T�rkiye
²Erzurum B�lge E�itim Ve Ara�t�rma Hastanesi Psikiyatri Klini�i, Erzurum, T�rkiye
³Erzurum B�lge E�itim Ve Ara�t�rma Hastanesi Dermatoloji Klini�i, Erzurum, T�rkiye
⁴�umra Devlet Hastanesi Psikiyatri Klini�i, Konya, T�rkiye

Ama�: Akne hastalar�nda dikkat, bellek, s�zel beceriler ve y�r�t�c� i�levler izotretinoin tedavisi �ncesi ve s�ras�nda de�erlendirildi.

Gere� ve Y�ntem: Elli iki tedavi almam�� akne hastas� ilk vizitte, kontrole gelen 24 hasta 2. vizitte de�erlendirildi. Rey ��itsel S�zel Bellek Testi, ��itsel ��l� Sessiz Harf S�ralama Testi, Kelime �a�r��m (KAS) testi, Say� Uzam Testi, �z S�rme A ve B testleri ve Stroop Testinden olu�an test bataryas� kullan�ld�. Ayn� zamanda DSM-IV Eksen I Bozukluklar� ��in Yap�land�r�lm�� Klinik G�r��me Formu (SCID-I), Hastane Anksiyete ve Depresyon �l�e�i ve Liebowitz Sosyal Kayg� �l�e�i de uyguland�.

Bulgular: �lk de�erlendirmeye g�re ikinci g�r��mede dikkat ve y�r�t�c� i�levlerde d�zelme saptand�. S�zel epizodik bellek, ��renme, i�lem belle�i ya da kelime ak�c�l��nda bir de�i�me saptanmad� (Say� Uzam� �leri p=0,003, �z S�rme Testi-A p=0,002, �z S�rme Testi-B p=0,000, Stroop testi p=0,028).

Sonu�: �zotretinoinin bili�sel i�levler �zerindeki olumlu etkisi akne lezyonlar�n�n azalmas� sonucu aknenin sosyal etkileri konusundaki zihinsel u�ra��n�n azalmas�na ba�lanabilir.

Anahtar Kelimeler: Akne, izotretinoin, bili�sel i�levler, bellek, y�r�t�c� i�levler, dikkat, s�zel ak�c�l�k

Erdem Deveci, Ahmet �zt�rk, �smet K�rp�nar, Rag�p �smail Engin, Mehmet Meliko�lu, Selcen Cafero�lu Sakat, Muhammet Demir, Serpil Canpolat. Improvement in Attention and Executive Functions During Isotretinoin Treatment in Patients With Acne. Turkderm-Turk Arch Dermatol Venereol. 2013; 47(2): 109-113

Corresponding Author: Erdem Deveci, T�rkiye

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