308 nm monochromatic excimer light (MEL) in dermatology

Se�kin, Dilek; Ergun, T�lin

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308 nm monochromatic excimer light (MEL) in dermatology [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2008; 42(3): 77-81

308 nm monochromatic excimer light (MEL) in dermatology

Dilek Se�kin, T�lin Ergun
Marmara University School Of Medicine, Department Of Dermatology, �stanbul, Turkey

�Targeted phototherapy� is a recently described therapeutic option in photodermatology. It is used to describe the phototherapy devices which can deliver high doses of ultraviolet (UV) radiation selectively to the involved skin. Several of these devices with different emission spectrums are currently in use. 308 nm monochromatic excimer light (MEL) is among these �targeted phototherapy� systems and represents one of the most important advances in phototherapy after the development of narrowband UVB. The wavelength of this new phototherapeutic option is very close to narrowband UVB. Many studies have been conducted to investigate the effectiveness of 308 nm MEL in several dermatological diseases, mainly psoriasis and vitiligo. Main advantages of MEL are protection of the healthy, uninvolved skin from excess UV radiation in patients with limited involvement and the much faster response to therapy compared with conventional phototherapies. We review in this article the properties of 308 nm MEL and discuss its current and future use in dermatology.

Keywords: Targeted phototherapy, excimer, monochromatic, MEL

Dermatolojide 308 nm monokromatik excimer ��k sistemleri

Dilek Se�kin, T�lin Ergun
Marmara �niversitesi T�p Fak�ltesi, Deri ve Z�hrevi Hastal�klar Anabilim Dal�, �stanbul, T�rkiye

�Hedefe y�nelik fototerapi�, y�ksek doz ultraviyole (UV) radyasyonunu k�sa s�re i�inde sadece lezyonlu deriye ula�t�ran fototerapi sistemleri i�in yak�n zamanda tan�mlanm�� bir kavramd�r. G�n�m�zde, farkl� emisyon spektrumuna sahip �e�itli hedefe y�nelik fototerapi sistemleri bulunmaktad�r. Bunlar i�erisinde yer alan 308 nm monokromatik excimer ��k (MEI) sistemleri, darbant UVB�den sonra, fototerapi alan�ndaki en �nemli yeniliklerden biridir. Dalga boyu a��s�ndan darbant UVB�ye olduk�a yak�n olan bu yeni fototerapi y�nteminin, ba�ta psoriasis ve vitiligo olmak �zere �e�itli dermatolojik hastal�klarda kullan�m�yla ilgili �ok say�da �al��ma bulunmaktad�r. 308 nm MEI�n�n en �nemli avantajlar�, �zellikle s�n�rl� deri tutulumu olan hastalarda sa�lam derinin gereksiz UV�ye maruz kalmas�n� �nlemesi ve tedavi yan�t�n�n, klasik fototerapi y�ntemlerine g�re �ok daha h�zl� elde edilmesidir. Bu makalede, 308 nm MEI sistemlerinin �zelliklerinden ve literat�rdeki bilgiler ��nda, hem g�n�m�zdeki hem de gelecekteki potansiyel kullan�m alanlar�ndan bahsedilmektedir.

Anahtar Kelimeler: Hedefe y�nelik fototerapi, excimer, monokromatik, MEI

Dilek Se�kin, T�lin Ergun. 308 nm monochromatic excimer light (MEL) in dermatology. Turkderm-Turk Arch Dermatol Venereol. 2008; 42(3): 77-81

Corresponding Author: Dilek Se�kin, T�rkiye

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