A case of atypical scleromyxedema mimicking angioedema which responded well to acitretin treatment

A 37-year-old male patient was admitted our clinic with complaints of edema and mild pruritus on the eyelids, ears, and neck. On dermatological examination there were pale erythema and edema on eyelids and ears; also coarsening of the facial skin and grooving in the forehead lines. In his medical history, it was learned that systemic corticosteroids, antihistamines and epinephrine treatments were given with the diagnosis of urticaria, angioedema for about two months, but he did not benefit from these treatments. A diagnosis of atypical scleromyxedema without monoclonal gammopathy was done according to the clinical, histopathological and laboratory findings. Acitretin treatment with a dose of 35 mg/day was started. Marked regression in the lesions was observed two months later.

Keywords: Angioedema, scleromyxedema, acitretin

Anjiyoödemi taklit eden ve asitretin tedavisine iyi yan?t veren atipik skleromiksödemli bir olgu

Otuz yedi ya??ndaki erkek hasta göz kapaklar?nda, kulaklar?nda, boyun ön ve yan yüzleri ile ensesinde ?i?lik ve hafif ka??nt? ?ikayeti ile poliklini?imize ba?vurdu. Dermatolojik muayenesinde göz kapaklar?nda ve kulaklar?nda soluk eritem ve ödem; yüz derisinde kabala?ma ve al?n bölgesinde oluklanmalar saptand?. Hastan?n öyküsünden yakla??k iki ayd?r ürtiker-anjioödem tan?lar? ile sistemik kortikosteroid, antihistaminik ve adrenalin tedavilerinin verildi?i fakat bu tedavilerden hiç fayda görmedi?i ö?renildi. Klinik, histopatolojik ve laboratuar bulgular?n?n ?????nda hastaya monoklonal gamopatisiz atipik skleromiksödem tan?s? konuldu. Hastaya asitretin (35 mg/gün) tedavisi ba?land?. ?ki ay sonra lezyonlarda belirgin düzelme gözlendi.

Anahtar Kelimeler: Anjiyoödem, skleromiksödem, asitretin