Clear cell basal cell carcinoma with neuroendocrine differentiation

Leblebici, Cem; Okcu, O�uzhan; Kelten, Canan; Koku Aksu, Ay�e Esra

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Clear cell basal cell carcinoma with neuroendocrine differentiation [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2016; 50(2): 73-76 | DOI: 10.4274/turkderm.01069

Clear cell basal cell carcinoma with neuroendocrine differentiation

Cem Leblebici¹, O�uzhan Okcu¹, Canan Kelten¹, Ay�e Esra Koku Aksu²
¹Department Of Pathology, �stanbul Education And Research Hospital, �stanbul, Turkey
²Department Of Dermatology, �stanbul Education And Research Hospital, �stanbul, Turkey

Basal cell carcinomas (BCC) are tumors arising from pluripotent stem cells of the epidermis or hair follicles. There are many histological subtypes such as clear cell, a rare variant, and they have the capacity to differentiate towards distinct directions such as neuroendocrine differentiation (NED). An 81-year-old female patient presented with a mass on the lateral side of the right eyebrow. Excisional biopsy was performed. Histopathologic examination revealed clear cell BCC with prominent rosette-like structures suggesting NED. Immunohistochemically, tumor cells were positive for chromogranin and CD56. This is the first reported case of clear cell basal carcinoma with NED.

Keywords: Basal cell carcinoma, neuroendocrine differentiation, clear cell

N�roendokrin diferansiyasyon g�steren berrak h�creli bazal h�creli karsinom

Cem Leblebici¹, O�uzhan Okcu¹, Canan Kelten¹, Ay�e Esra Koku Aksu²
¹�stanbul E�itim Ve Ara�t�rma Hastanesi T�bbi Patoloji B�l�m�, �stanbul, T�rkiye
²�stanbul E�itim Ve Ara�t�rma Hastanesi Dermatoloji Klini�i, �stanbul, T�rkiye

Bazal h�creli karsinomlar (BHK) epidermis ya da k�l folik�l�ndeki pluripotent k�k h�creden ��kan t�m�rlerdir. Nadir g�r�len berrak h�creli varyant� gibi �ok say�da histolojik alt tipi olup n�roendokrin diferansiyasyon (NED) gibi de�i�ik y�nlere diferansiyasyon kapasitesine sahiptirler. Seksen bir ya��nda kad�n hasta sa� ka� �zerinde kitle �ikayeti ile ba�vurdu. Uygulanan eksizyonel biyopsi materyalinin histolojik incelemesinde NED�i d��nd�ren rozet benzeri yap�lar olu�turan berrak h�creli BHK g�r�ld�. �mm�nhistokimyasal �al��mada t�m�r h�creleri kromogranin ve CD56 ile pozitif boyand�. Bu olgu literat�rde bildirilen NED g�steren ilk berrak h�creli BHK olgusudur.

Anahtar Kelimeler: Bazal h�creli karsinom, n�roendokrin diferansiyasyon, berrak h�cre

Corresponding Author: Cem Leblebici, T�rkiye
Manuscript Language: Turkish

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