A case of lupus panniculitis treated with dapsone

Lupus panniculitis is a rare and unusual form of lupus erythematosus with subcutaneous inflammation of adipose tissue. Successful use of dapsone in lupus panniculitis was reported in a few cases refractory to systemic corticosteroids and antimalarial agents. A 43-year-old female patient has been suffering from asymptomatic, erythematous, indurated plaques on the forehead, nose and ear started two years ago, which were followed by several subcutaneous nodules on the arms. Diagnosis of lupus panniculitis was confirmed by histopathological findings of the skin biopsy. Dapsone, 100mg/day was administered for 4 weeks and continued 50mg daily for another 18-week-period. This case is presented because of its rarity and responsivity to dapsone treatment.

Dapsonla Tedavi Edilen Bir Lupus Panniküliti Olgusu

Lupus panniküliti, lupus eritematozusun yað dokusu inflamasyonu ile giden ve nadir görülen bir formudur. Sistemik kortikosteroid ve antimalaryallere yanýt vermeyen olgularda dapsonun baþarýyla kullanýmý bildirilmiþtir. Ýki yýl önce alýn, burun ve kulakta baþlayýp kollara yayýlan, asemptomatik, indure nodül ve plaklarla baþvuran 43 yaþýndaki kadýn hastanýn deri biyopsisinde histopatolojik bulgular lupus panniküliti ile uyumlu bulundu. Dört hafta 100mg/gün dapson kullanan hastanýn lezyonlarýnda düzelme izlenmesi üzerine 50mg/gün dozda 18 hafta süreyle tedavisine devam edildi. Olgumuz nadir görülmesi ve dapsona yanýt vermesi nedeniyle sunulmuþtur.