Turkderm-Turk Arch Dermatol Venereol. 2015; 49(1): 54-59 | DOI: 10.4274/turkderm.02259

Comparison of the efficacy and safety of topical clindamycin and 5% benzoyl peroxide with nadifloxacin cream and 5% benzoyl peroxide gel in the treatment of acne vulgaris and assessment of the effects of these treatments on quality of life

Aslýhan Kýrkaðaç¹, Zeynep Nurhan Saraçoðlu², Ayþe Esra Koku Aksu^3
1Marmaris Ozel Yucelen Hospital, Dermatology Clinic
²Eskisehir Osmangazi University, Faculty Of Medicine, Department Of Dermatology
³Istanbul Training And Research Hospital Department Of Dermatology

Background and Design: Acne vulgaris is a multifactorial chronic inflammatory disase of the pilosebaceous unit. Topical antibiotics and anti-inflammatory treatment are used for mild and moderate acne. Clindamycin is frequently used for acne treatment, altough nadifloxacin is a relatively new agent. There are few studies evaluating nadifloxacin efficacy. It's impact on quality of life has not been determined previously. In this study, it is aimed to compare the effect of these two agents, and to evaluate the effect of these treatments on quality of life. 
Materials and Methods: Eighty patients with mild-moderate acne vulgaris were divided in two groups of 40 people that had no difference in terms of age, gender and acne severity. The combination of topical clindamycin and 5% benzoyl peroxide gel twice a day was given to group 1 for 12 weeks. The combination of nadifloxacin cream and 5% benzoyl peroxide gel twice a day was given to group 2 for 12 weeks. The number of the inflammatory and non-inflammatory lesions were recorded at baseline and on weeks 2, 4, 8, 12 and side effects were recorded and evaluated. Global improvement was evaluated separately by patients and doctor after the treatment. Before and after the treatment, the quality of life of the patients were evaluated with Skindex-29. 
Results: Both treatment group regimens were significantly effective on inflammatory and non-inflammatory lesions and were well tolerated by patients in terms of side effects. It was also observed that there was statistically significant recovery after treatment in terms of clinical severity and quality of life. There was not any statistically significant difference between two treatment methods in terms of effectiveness, side effect and quality of life.
Conclusion: Nadifloxacin and 5% benzoyl peroxide combination is effective in the treatment and improvement of quality of life in acne patients.

Keywords: Acne vulgaris, clindamycin, nadifloxacin, quality of life

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Akne vulgaris tedavisinde topikal klindamisin ve %5 benzoil peroksit ile nadifloksasin ve %5 benzoil peroksit kombinasyonunun tedavideki etkinliðinin ve güvenilirliðinin ve yaþam kalitesi üzerine etkisinin deðerlendirilmesi

Aslýhan Kýrkaðaç¹, Zeynep Nurhan Saraçoðlu², Ayþe Esra Koku Aksu^3
1Marmaris Özel Yücelen Hastanesi, Dermatoloji Kliniði, Muðla, Türkiye
²Eskiþehir Osmangazi Üniversitesi Týp Fakültesi, Dermatoloji Anabilim Dalý, Eskiþehir, Türkiye
³Ýstanbul Eðitim Ve Araþtýrma Hastanesi, Dermatoloji Kliniði, Ýstanbul, Türkiye

Amaç: Akne vulgaris pilosebase ünitenin multifaktöriyel, kronik inflamatuar bir hastalýðýdýr. Hafif-orta þiddetli aknede topikal antibiyotik ve antiinflamatuar tedavi ön plandadýr. Klindamisin topikal antibiyotik olarak sýk kullanýlan bir ajandýr, nadifloksasin ise göreceli olarak daha yeni kullanýlmaya baþlayan bir ajandýr. Nadifloksasinin tedavi etkinliðinin karþýlaþtýrýldýðý sýnýrlý sayýda çalýþma mevcuttur. Yaþam kalitesi üzerine olan etkisi ise daha önce deðerlendirilmemiþtir. Bu çalýþmada bu iki ajanýn etkisinin karþýlaþtýrýlmasý ve yaþam kalitesi üzerine olan etkisinin deðerlendirilmesi planlandý.
Gereç ve yöntemler: Hafif ve orta þiddetli akne vulgarisi olan 80 hasta, yaþ, cinsiyetiyet ve akne dereceleri açýsýndan farklýlýk olmayan 40’ar kiþilik 2 gruba ayrýldý. Birinci grupta hastalar topikal klindamisin ve %5 benzoil peroksit kombinasyonu jel tedavisini günde 2 kez, ikinci grupta hastalar nadifloksasin krem ve %5 benzoil peroksit jel kombinasyonu tedavisini günde 2 kez olmak üzere 12 hafta süreyle kullandý. 0, 2, 4, 8 ve 12. haftalarda inflamatuar ve inflamatuar olmayan lezyonlarýn sayýsý kaydedildi, oluþan yan etkiler deðerlendirildi. Ýyileþme hasta ve doktor için ayrý olmak üzere tedavi sonunda deðerlendirildi. Tedavi öncesi ve sonrasýnda hastalarýn yaþam kalitesi dermatolojiye özel yaþam kalite ölçeði olan Skindeks-29 ile deðerlendirildi. 
Bulgular: Her iki grupta da tedavinin, hem inflamatuar hem de noninflamatuar lezyonlara istatistiksel olarak anlamlý azalma saptandý. Hastalar tarafýndan iyi tolere edildi. Her iki tedavi grubunda da yaþam kalitesi üzerinde istatistiksel olarak anlamlý düzelme saðlandý. Ýki tedavi yöntemi arasýnda etkinlik, yan etki ve yaþam kalitesinin düzelmesi açýsýndan istatistiksel olarak anlamlý fark saptanmadý. 
Sonuç: Nadifloksasin krem %5 benzoil peroksit kombinasyonu, klindamisin ve %5 benzoil peroksit kombinasyonu kadar tedavide ve yaþam kalitesinin düzelmesinde etkilidir.

Anahtar Kelimeler: Akne vulgaris, klindamisin, nadifloksasin, yaþam kalitesi

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