Turkderm-Turk Arch Dermatol Venereol. 2020; 54(1): 19-21 | DOI: 10.4274/turkderm.galenos.2019.13845

Treatment of tuberous sclerosis facial angiofibromas with erbiumyttrium aluminium garnet laser and topical sirolimus 0.25%

Ayþenur Botsalý¹, Ercan Çalýþkan¹, Kadir Küçük¹, Ýrfan Gahramanov¹, Cansel Köse Özkan^2
1University of Health Sciences Turkey, Gülhane Training and Research Hospital, Clinic of Dermatology, Ankara, Turkey
²University of Health Sciences Turkey, Gülhane School of Pharmacy, Department of Pharmaceutical Technology, Ankara Turkey

Although the efficacy of topical sirolimus for facial angiofibromas of tuberosclerosis is now appreciated, drug-induced irrritation complicates the use of the concentration recommended in the literature as 1%. Adjuvant vascular or ablative laser applications may be preferred in adult patients for a variety of purposes, such as treatment of large lesions that tend to be resistant to topical treatment, reduction of topical product concentration and rapid response generation. Herein, we aimed to share the 2-year follow up result of a tuberoussclerosis case where angiofibromas were observed on the chin, malar regions and nose. We combined the full-field erbium-yttrium aluminium garnet laser application with topical sirolimus 0.25% cream on the second month of treatment.

Keywords: Erbium-YAG laser, sirolimus, mTOR inhibitor, angiofibroma

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Tüberoskleroz yüz anjiyofibromlarýnýn erbium-itriyum alüminyum garnet lazer ve topikal sirolimus %0,25 ile tedavisi

Ayþenur Botsalý¹, Ercan Çalýþkan¹, Kadir Küçük¹, Ýrfan Gahramanov¹, Cansel Köse Özkan^2
1Saðlýk Bilimleri Üniversitesi Gülhane Eðitim Araþtýrma Hastanesi Dermatoloji Anabilim Dalý
²Saðlýk Bilimleri Üniversitesi Gülhane Eczacýlýk Fakültesi Farmasötik Teknoloji Anabilim Dalý

Tüberosklerozun yüz yerleþimli anjiyofibromlarýnda topikal sirolimusun etkinliði artýk iyi bilinmekle birlikte ilaca baðlý irritasyon literatürde önerilen %1 konsantrasyonun kullanýmýný zorlaþtýrmaktadýr. Adjüvan vasküler veya ablatif lazer uygulamalarý, topikal tedaviye dirençli olma eðilimi gösteren büyük lezyonlarýn tedavisi, kullanýlan topikal ürün deriþiminin azaltýlmasý ve hýzlý yanýt eldesi gibi çeþitli amaçlar için eriþkin hastalarda tercih edilebilir. Biz burada çene, burun, malar bölgelerde yaygýn yerleþimli anjiyofibroma lezyonlarý izlenen bir tüberoskleroz olgumuzun 2 yýllýk takip sonucunu paylaþmayý amaçladýk. Bu olgunun yönetiminde tüm-saha erbium-itriyum alüminyum garnet lazer uygulamasýný, tedavi sonrasý ikinci ayda %0,25 dozda topikal sirolimus kullanýmý ile kombine ettik.

Anahtar Kelimeler: Erbium-YAG lazer, sirolimus, mTOR inhibitörü, anjiyofibrom

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