Turkderm-Turk Arch Dermatol Venereol. 2020; 54(3): 114-118 | DOI: 10.4274/turkderm.galenos.2020.32068

Periorbital lupus erythematosus profundus: A case report and review of the literature

Didem Mullaaziz¹, Serap Maden¹, Orgun Deren², Hanife Özkayalar^3
1Near East University Faculty of Medicine, Department of Dermatology and Venereology, Nicosia, Cyprus
²Near East University Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Nicosia, Cyprus
³Near East University Faculty of Medicine, Department of Pathology, Nicosia, Cyprus

Lupus erythematosus profundus (LEP), is a rare form of, chronic cutaneous LE, also called lupus erythematosus panniculitis. LEP is characterized by subcutaneous fatty tissue involvement spesifically in patients with LE. Before systemic LE was diagnosed, very few reports reported the presence of lesions of lupus erythematosus profundus. The rare manifestations of the disease are remarkable with the unusual features of the cases. A 43-year-old female patient diagnosed with bilateral periorbital LEP was presented and the literature was reviewed. Significant clinical improvement was achieved in the patient who was given systemic hydroxychloroquine and topical pimecrolimus therapy. This report suggests that asymptomatic periorbital erythema and edema may develop as a manifestation of LEP.

Keywords: Lupus erythematosus, lupus erythematosus profundus, lupus panniculitis, orbital area

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Periorbital lupus eritematozus profundus: Bir olgu sunumu ve literatürün gözden geçirilmesi

Didem Mullaaziz¹, Serap Maden¹, Orgun Deren², Hanife Özkayalar^3
1Near East University Faculty of Medicine, Department of Dermatology and Venereology, Nicosia, Cyprus
²Near East University Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Nicosia, Cyprus
³Near East University Faculty of Medicine, Department of Pathology, Nicosia, Cyprus

Lupus eritematozus profundus (LEP), nadir görülen bir kronik kutanöz lupus eritematozus türü olup, lupus eritematozus panniküliti olarak da adlandýrýlmaktadýr. LEP, LE hastalarýnda spesifik olarak subkutan yað doku tutulumu ile karakterizedir. Sistemik lupus eritematozus tanýsý konulmadan önce LEP lezyonlarýnýn varlýðýný bildiren çok az sayýda rapor bildirilmiþtir. Hastalýðýn nadir görülen bulgularý, olgularýn sýra dýþý özellikleri ile dikkat çekici olmaktadýr. Burada bilateral periorbital LEP tanýsý konulan, 43 yaþýnda bir kadýn olgu sunulmuþ ve literatür gözden geçirilmiþtir. Sistemik hidroksiklorokin ve topikal pimekrolimus tedavisi verilen hastada anlamlý klinik iyileþme saðlanmýþtýr. Bu rapor, asemptomatik periorbital eritem ve ödemin LEP’nin bir bulgusu olarak geliþebileceðini desteklemektedir.

Anahtar Kelimeler: Lupus eritematozus, lupus eritematozus profundus, lupus panniküliti, orbital alan

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