Turkderm-Turk Arch Dermatol Venereol. 2022; 56(1): 28-33 | DOI: 10.4274/turkderm.galenos.2021.69797

Correlation between serum uric acid, C-reactive protein, and neutrophil-to-lymphocyte ratio in patients with psoriasis: A case-control study

Swayamsidda Mishra¹, Manjunath Kadnur², Shishira R Jartarkar², Hanumanthayya Keloji³, Ritu Agarwal⁴, Spoorthy Babu^2
1Vaccicare Clinic, Department of Dermatology, Cuttack, India
²Vydehi Institute of Medical Sciences and Research Center, Department of Dermatology, Venereology and Leprosy, Bangalore, India
³Sri Devaraj Urs Medical College, Department of Dermatology, Venereology and Leprosy, Kolar, India
⁴Kaya Skin Clinic, Department of Dermatology, Mumbai, India

Background and Design: Although multiple investigations have been conducted to identify important serum biomarkers in patients with psoriasis, no simple, useful biomarker that could be specific for psoriasis has been identified. Objectives: 1) To determine the levels of serum uric acid (SUA), C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio (NLR) among individuals with psoriasis and controls, 2) to assess the correlation of SUA and CRP levels and NLR with disease severity calculated through the psoriasis area severity index (PASI) in patients with psoriasis.
Materials and Methods: A hospital-based, case-control study included 45 patients clinically diagnosed with psoriasis and 45 age- and sexmatched controls attending the outpatient dermatology clinic of our hospital. After a complete history was taken, and general, systemic, and cutaneous examinations were performed, all the cases were subjected to the following investigations: Complete blood count (NLR), CRP, and SUA.
Results: Mean SUA level was significantly higher in the patients with psoriasis compared to the controls (p<0.01). However, no difference in CRP levels and NLR was observed (p>0.05). A significant correlation of SUA level and NLR was found with disease severity in the patients with psoriasis as determined by the PASI. In multivariate analysis, only SUA was found to be independently associated with psoriasis severity (p<0.05).
Conclusion: The results showed that only SUA to be independently associated with psoriasis severity. No association was found between CRP levels and NLR and disease severity, as well as no difference between the disease and controls groups.

Keywords: C-reactive protein, neutrophil-to-lymphocyte ratio, psoriasis, serum uric acid

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Serum ürik asit, C-reaktif protein ve nötrofil/lenfosit oranýnýn psoriazis ile iliþkisi: Bir olgu kontrol çalýþmasý

Swayamsidda Mishra¹, Manjunath Kadnur², Shishira R Jartarkar², Hanumanthayya Keloji³, Ritu Agarwal⁴, Spoorthy Babu^2
1Vaccicare Kliniði, Dermatoloji Anabilim Dalý, Cuttack, Hindistan
²Vydehi Týp Bilimleri Enstitüsü ve Araþtýrma Merkezi, Dermatoloji, Venereoloji ve Lepra Anabilim Dalý, Bangalore, Hindistan
³Sri Devaraj Urs Týp Fakültesi, Dermatoloji, Venereoloji ve Lepra Anabilim Dalý, Kolar, Hindistan
⁴Kaya Skin Kliniði, Dermatoloji Anabilim Dalý, Mumbai, Hindistan

Amaç: Psoriazisli hastalarýn periferik kan örneklerinde yararlý biyobelirteçler bulmak amacýyla çok sayýda araþtýrma yapýlmýþ olmasýna raðmen, psoriazise özgü olabilecek basit ve klinik olarak yararlý bir biyobelirteç tanýmlanmamýþtýr. Hedefler: 1) Psoriazisli hastalar ve kontroller arasýnda serum ürik asit (SÜA), C-reaktif protein (CRP) ve nötrofil/lenfosit oranýný (NLO) belirlemek, 2) psoriazisi olan hastalarda SÜA seviyeleri, CRP, nötrofil/lenfosit oraný ve psoriazis alan þiddet indeksi (PAÞÝ) ile hesaplanan hastalýk þiddeti arasýndaki iliþkiyi deðerlendirmektir.
Gereç ve Yöntem: Hastane bazlý bir olgu kontrol çalýþmasýna, hastanemizin dermatoloji polikliniðine baþvuran, klinik olarak teþhis edilmiþ 45 psoriazis olgusu, 45 yaþ ve cinsiyet uyumlu kontrol dahil edilmiþtir. Tam öykü, genel, sistemik ve kutanöz muayeneleri yapýldýktan sonra tüm olgularda tam kan sayýmý (NLO), CRP ve SÜA incelemeleri yapýlmýþtýr.
Bulgular: Psoriazis olgularý arasýnda ortalama SÜA düzeyi kontrollere göre anlamlý derecede yüksekti (p<0,01). Ancak CRP düzeyleri ve NLO arasýnda fark gözlenmedi (p>0,05). Psoriazisli hastalarda SÜA ve NLO ile, PAÞÝ skoru ile belirlenen hastalýk þiddeti arasýnda anlamlý bir korelasyon gözlendi. Çok deðiþkenli analizde, sadece SÜA’nýn, psoriazis þiddeti ile baðýmsýz olarak bir iliþki gösterdiði belirlendi (p<0,05).
Sonuç: Bu çalýþmanýn sonuçlarý, yalnýzca SÜA’nýn baðýmsýz olarak psoriazis þiddeti ile iliþkili olduðunu gösterdi. CRP seviyeleri ile NLO ve hastalýk þiddeti arasýnda hiçbir iliþki gözlenmedi, hastalýk ve kontrol gruplarý arasýnda da herhangi bir fark kaydedilmedi.

Anahtar Kelimeler: C-reaktif protein, nötrofil-lenfosit oraný, psoriazis, serum ürik asit

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