Turkderm-Turk Arch Dermatol Venereol. 2022; 56(2): 86-121 | DOI: 10.4274/turkderm.galenos.2022.73368

Atopic dermatitis diagnosis and treatment consensus report

Nilgün Atakan¹, Baþak Yalçýn¹, Esen Özkaya², Özlem Su Küçük³, Serap Öztürkcan⁴, Andaç Salman⁵, Murat Borlu⁶, Nilgün Þentürk⁷, Ayþe Akman-Karakaþ⁸, Server Serdaroðlu^9
1Dermatology Private Practice, Ankara, Turkey
²Ýstanbul University, Ýstanbul Faculty of Medicine, Department of Dermatology, Ýstanbul, Turkey
³Bezmialem Vakýf University Faculty of Medicine, Department of Dermatology, Ýstanbul, Turkey
⁴Celal Bayar University Faculty of Medicine, Department of Dermatology, Manisa, Turkey
⁵Acýbadem Mehmet Ali Aydýnlar University Faculty of Medicine, Department of Dermatology, Ýstanbul, Turkey
⁶Erciyes University Faculty of Medicine, Department of Dermatology, Kayseri, Turkey
⁷Ondokuz Mayýs University Faculty of Medicine, Department of Dermatology, Samsun, Turkey
⁸Dermatology Private Practice, Ýstanbul, Turkey
⁹Ýstanbul University-Cerrahpaþa, Cerrahpaþa Faculty of Medicine, Department of Dermatology, Ýstanbul, Turkey

Atopic dermatitis (AD) is a chronic, itchy, and recurrent inflammatory skin disease. AD, which is known as a childhood disease because of its common occurrence, is also an important health problem in adults. With increasing prevalence rates throughout each year, particularly in developed countries, AD has a heterogeneous clinical presentation that varies with age and different degrees of severity. The treatment includes the use of topical or systemic agents after identifying the needs of the patients. Especially, the identification of molecules responsible for pathogenesis recently has allowed the development of tailored treatments. With a better understanding of both the disease and the economic burden of AD recently, studies have gained momentum on diagnosis, treatment, and quality of life. Guidelines and consensus reports addressing diagnostic and therapeutic approaches have been published in our country, too, in parallel to publications in various countries. In this age of rapid information sharing, all kinds of information need to be updated frequently and become further useful. For this purpose, it is planned to develop a current consensus guideline under the leadership of the Dermatoimmunology and Allergy Association, with the contributions of the Cosmetology and the Dermatology Academy Association, Kayseri Dermatology and the Venereal Diseases Association, and Manisa Dermatology and the Venereal Diseases Association, and through the participation of faculty members experienced in the diagnosis and treatment of AD. The topics and the authors were chosen in December 2020. All Medline data published in the years between 1980 and 2021, current AD diagnosis and treatment guidelines, meta-analytical studies, and expert opinions and experiences were reviewed, and section drafts were developed. Literature data and section drafts were assessed and discussed during a meeting held in March 2021 with the participation of all authors. Then, the sections were finalized via e-mail correspondences and submitted as a final consensus report.

Keywords: Atopic dermatitis, guideline, diagnosis, topical treatment, systemic treatment

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Atopik dermatit taný ve tedavi uzlaþý raporu

Nilgün Atakan¹, Baþak Yalçýn¹, Esen Özkaya², Özlem Su Küçük³, Serap Öztürkcan⁴, Andaç Salman⁵, Murat Borlu⁶, Nilgün Þentürk⁷, Ayþe Akman-Karakaþ⁸, Server Serdaroðlu^9
1Dermatoloji Özel Klinik, Ankara, Türkiye
²Istanbul Üniversitesi Istanbul Týp Fakültesi, Deri Ve Zührevi Hastalýklarý Ana Bilim Dalý, Istanbul, Türkiye
³Bezmialem Vakýf Üniversitesi Týp Fakültesi, Dermatoloji Ana Bilim Dalý, Istanbul, Türkiye
⁴Celal Bayar Üniversitesi Týp Fakültesi, Deri Ve Zührevi Hastalýklarý Ana Bilim Dalý, Manisa, Türkiye
⁵Acýbadem Mehmet Ali Aydýnlar University Faculty of Medicine, Department of Dermatology, Ýstanbul, Turkey
⁶Erciyes Üniversitesi Týp Fakültesi, Dermatoloji Ana Bilim Dalý, Kayseri, Türkiye
⁷Ondokuz Mayýs Üniversitesi Týp Fakültesi, Dermatoloji Ana Bilim Dalý, Samsun, Türkiye
⁸Dermatology Private Practice, Ýstanbul, Turkey
⁹Istanbul Üniversitesi Cerrahpaþa Týp Fakültesi, Deri Ve Zührevi Hastalýklarý Ana Bilim Dalý, Istanbul, Türkiye

Atopik dermatit (AD) kronik, kaþýntýlý ve tekrarlayan enflamatuvar bir deri hastalýðýdýr. Sýk görülmesi nedeni ile çocukluk çaðý hastalýðý olarak bilinen AD, eriþkinlerde de önemli bir saðlýk problemi olarak karþýmýza çýkmaktadýr. Her geçen yýl özellikle geliþmiþ ülkelerde görülme sýklýðý artan AD, yaþla deðiþen heterojen bir kliniðe sahiptir ve farklý þiddette seyretmektedir. Tedavi, hastalarýn ihtiyacý belirlenerek topikal veya sistemik ajanlarla sürdürülür. Özellikle son yýllarda patogenezden sorumlu moleküllerin tanýmlanmasý kiþiye özel tedavilerin geliþtirilmesine olanak tanýmýþtýr. Son yýllarda AD’nin hem hastalýk hem de ekonomik yükünün daha iyi anlaþýlmasý ile taný, tedavi ve yaþam kalitesine iliþkin çalýþmalar hýz kazanmýþtýr. Çeþitli ülkelerde olduðu gibi ülkemizde de taný ve tedavi yaklaþýmlarý içeren kýlavuzlar ve uzlaþý raporlarý yayýnlanmaya baþlamýþtýr. Yaþadýðýmýz hýzlý bilgi paylaþýmý çaðýnda, tüm bilgilerin sýk sýk yenilenmesine ve daha yararlý hale getirilmesine ihtiyaç vardýr. Bu amaçla, Dermatoimmünoloji ve Alerji Derneði öncülüðünde Kozmetoloji ve Dermatoloji Akademisi Derneði, Kayseri Deri ve Zührevi Hastalýklarý Derneði ve Manisa Deri ve Zührevi Hastalýklar Derneði’nin katkýlarý ve AD taný ve tedavisinde deneyimli öðretim üyelerinin katýlýmý ile güncel bir uzlaþý kýlavuzu hazýrlanmasý planlanmýþtýr. Öncelikle Aralýk 2020’de konu baþlýklarý ve yazarlar belirlenmiþ ve 1980-2021 yýllarý arasýnda yayýmlanan tüm Medline verileri, güncel AD taný ve tedavi kýlavuzlarý, meta-analitik çalýþmalar ve uzman görüþ ve deneyimleri doðrultusunda bölümler yazýlmýþtýr. Tüm yazarlarýn katýlýmýyla Mart 2021’de gerçekleþtirilen toplantýda literatür verileri ve bölüm taslaklarý deðerlendirilmiþ, tartýþýlmýþ ve elektronik posta yazýþmalarý ile son þekli verilerek uzlaþý raporu olarak sunulmuþtur.

Anahtar Kelimeler: Atopik dermatit, kýlavuz, taný, topikal tedavi, sistemik tedavi

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