Assesment of acne vulgaris patients’ attention tests during the isotretinoin treatment

Background and Design: This study aimed to investigate any relationship between an emerging attention deficit in patients with acne vulgaris and have reached cumulative doses under isotretinoin treatment. Materials and Methods: A total of 100 patients (aged: 16-40 years) with acne vulgaris who have reached cumulative doses under isotretinoin medication for over a period of 6 months were included in the study. Using the Stroop Color and Word Test (SCWT), attention was assessed in the patients at the beginning and 3rd and 6th month of the treatment. Results: A repeated measures ANOVA analysis was performed to determine whether there was any change in the SCWT results over time after the first dose and 3rd and 6th month of the treatment. The changes in all SCWT results were statistically significant with respect to time. The time required for each task assessed by means of the SCWT was found to be significantly reduced over time. Conclusion: After evaluating the results of the SCWT performed at the beginning and 3rd and 6th month of the treatment, it was concluded that the treatment with the cumulative doses of isotretinoin was not significantly associated with any emerging attention deficit symptoms or signs in patients with acne vulgaris. It is possible that the patients were trained during the SCWT with the repeated performances in the study, which may have resulted a significant decrease in the test duration. This prospective study suggests that there is no casual relationship between the use of isotretinoin and attention deficit in patients with acne vulgaris

Akne vulgarisli hastalarýn isotretinoin tedavisi sýrasýnda dikkat ölçümlerinin deðerlendirilmesi

Amaç: Çalýþmada isotretinoin tedavisi baþlanan ve kümülatif doza ulaþan hastalarda tedavi süresince ilaç kullanýmý ile dikkat eksikliði arasýndaki bir iliþkinin olup olmadýðýnýn tanýmlanarak literatüre katkýda bulunmasý amaçlanmýþtýr. Gereç ve Yöntem: Akne vulgaris tanýsýyla isotretinoin tedavisi baþlanan ve kümülatif doza ulaþan 16-40 yaþ arasý 100 hasta çalýþmaya alýnmýþtýr. Hastalarýn tedavinin baþlangýçýnda, tedavinin 3. ayýnda ve 6. ayýnda Stroop testi ile dikkat ölçümleri (SCWT) deðerlendirilmiþtir. Bulgular: Hastalara ilk baþvurularýnda, tedavinin 3. ayýnda ve 6. ayýnda Stroop testi uygulanarak elde edilen SCWT ölçümlerinin zamana göre deðiþip deðiþmediðini belirlemek için tekrarlý ölçüm ANOVA analizi yapýlmýþtýr. Stroop testine ait tüm ölçümlerin zamana göre deðiþimi istatistiksel olarak anlamlýdýr. Her beþ ölçüme ait sürelerin zamana göre anlamlý olarak azaldýðý tespit edilmiþtir. Sonuç: Ýsotretionin baþlanan kümülatif doza ulaþan hastalarýn tedavi baþlangýcýnda, tedavinin 3. ayýnda ve 6. ayýnda yapýlan Stroop testi sonuçlarý, isotretinoin tedavisi ile dikkat eksikliði arasýnda bir iliþkinin olmadýðýný testlerin okunma sürelerinde görülen anlamlý azalmanýn, katýlýmcýlarýn Stroop testini öðrenme etkisinden kaynaklanmýþ olabileceði düþünülmüþtür. Bu prospektif çalýþma, isotretinoin kullanýmý ile dikkat eksikliði arasýnda nedensel bir baðlantý olmadýðýný göstermektedir.