Turkderm-Turk Arch Dermatol Venereol. 2014; 48(2): 85-86 | DOI: 10.4274/turkderm.48.s20

Radiation recall dermatitis induced by trastuzumab

Emre Kaynak¹, Þirin Yaþar¹, Fatih Göktay¹, Filiz Cebeci¹, Sema Aytekin¹, Pembegül Güneþ^2
1Haydarpasa Numune Training and Research Hospital Department of Dermatology
²Haydarpasa Numune Training and Research Hospital Department of Pathology

Radiation recall phenomenon is an acute, egzematous reaction that develops throughout a previously irradiated area, precipitated by the administration of docetaxel, doxorubicin, gemcitabine and paclitaxel. We report a 52-year-old woman with breast cancer who received locoregional radiotherapy followed by trastuzumab monotherapy. Three day after the first cycle of trastuzumab monotherapy, dermatitis developed in the previously irradiated skin.

Keywords: Trastuzumab, radiation recall dermatitis, breast cancer

---

Trastuzumab ile uyarýlan radyasyon anýmsatma dermatiti

Emre Kaynak¹, Þirin Yaþar¹, Fatih Göktay¹, Filiz Cebeci¹, Sema Aytekin¹, Pembegül Güneþ^2
1Haydarpaþa Numune Eðitim ve Araþtýrma Hastanesi, Dermatoloji, Ýstanbul, Türkiye
²Haydarpaþa Numune Eðitim ve Araþtýrma Hastanesi, Patoloji Kliniði, Ýstanbul, Türkiye

Radyasyon recall-anýmsatma dermatiti daha önceden radyoterapi uygulanan alanda sýklýkla docetaxel, doxorubicin, gemcitabine ve paclitaxel gibi kemoterapotik ilaçlarýn uygulanmasý ile ortaya çýkan akut, ekzematöz tablodur. Burada meme kanseri sonrasýnda lokal radyoterapi uygulanan ve ardýndan trastuzumab monoterapisi baþlanan 52 yaþýnda bayan olgu sunulmaktadýr. Trastuzumab tedavisinin ilk siklusundan 3 gün sonra daha
önce radyasyon alan deride akut dermatit geliþmiþtir.

Anahtar Kelimeler: Trastuzumab, radyasyon anýmsatma dermatiti, meme kanseri

---

CITE