Multiple cutaneous and Uterine Leiomyomatosis syndrome (Reed’s syndrome)

Cutaneous leiomyomas are rare benign tumors arising from smooth muscle cells. The combination of cutaneous leiomyomatosis, uterine leiomyomatosis and renal cell cancer is referred to as ‘‘multiple cutaneous and uterine leiomyomatosis syndrome (Reed’s Syndrome)’’. A forty-five-year-old female patient was admitted to our clinic with multiple painful bumps on the body. Diabetes mellitus and hysterectomy operation due to leiomyoma were present in her past medical history. Dermatologic examination revealed multiple, painful, skin coloured-red papulonodules forming clusters on the bilateral lomber area and a few lesions on right arm and back. Histopathological examination of the biopsy diagnosed as leiomyoma. The patient was treated with gabapentin which she had relief from pain at the end of 1 month.

Multipl kutanöz ve Uterin Leiyomiyomatozis sendromu (Reed sendromu)

Kutanöz leiyomiyomlar düz kas hücrelerinden köken alan, derinin nadir görülen tümörleridir. Kutanöz leiyomiyomatosis ile uterus leiyomiyomlarýnýn birlikteliði ile renal hücreli kanserin de eþlik edebildiði sendrom ‘‘multiple kutanöz ve uterin leiomyomatozis sendromu (Reed Sendromu)’’ þeklinde adlandýrýlmaktadýr. Kýrk beþ yaþýnda kadýn, gövdede aðrýlý þiþlikler þikayetiyle polikliniðimize baþvurdu. Özgeçmiþinde Tip 2 diyabetes mellitus ve multiple uterin leiyomiyomlar nedeniyle histerektomi operasyonu mevcuttu. Dermatolojik muayenede gövdede bilateral lomber bölgelerde yerleþen grube, sað kol ve sýrtta birkaç adet, dokunmakla hassas, deri renginde-kýrmýzýmsý, infiltre papülonodüler lezyonlar görüldü. Papüllerden alýnan biyopsinin histopatolojik incelemesi leiyomiyom ile uyumluydu. Hastaya aðrýlarýna yönelik gabapentin tedavisi baþlandý ve 1 ay sonundaki kontrolde aðrýlarda azalma gözlendi.