Impact of intense pulse light on quality of life in patients with erythematotelangiectatic rosacea

Background and Design: It has been shown that acne rosacea (AR) seriously affects quality of life (QoL). Various options are available for the treatment of AR. There are many studies in the literature demonstrating that QoL of patients have improved after these treatments. Positive outcomes have been attained with intense pulsed light (IPL) in the treatment of AR and erythematotelangiectatic rosacea (ETR) in particular. However, although there are studies in the literature showing the effectiveness of IPL in ETR, no studies have been conducted at either international or national level showing to what extent it has positive impact on QoL.
Materials and Methods: Our goal in this study was to reveal to what extent IPL affects QoL positively. To this end, 30 patients who were diagnosed with ETR and met the inclusion criteria were included in the study. In this open-label, prospective, uncontrolled cohort study, visual analog scale (VAS), Physician’s Global Assessment (PGA), Dermatology Life Quality Index (DLQI) and 36-Item Short Form Health Survey (SF-36) were administered before and after the IPL therapy, which was planned to be administered to the patients once in four weeks in a total of three sessions.
Results: The data collected before the first session and after the last session were evaluated with the SPSS statistics software and statistically significant p values were obtained. The difference in VAS score between before and after treatment was -3.13±1.46 (p<0.01), -1.6±0.6 in PGA (p<0.01), and -11.63±3.13 in DLQI (p<0.01). The SF-36 was assessed in 8 subscales; physical functioning (PF), role-physical (RP), social functioning (SF), role-emotional (RE), bodily pain (BP), vitality (VT), mental health (MH), and general health (GH). The statistical analysis of the SF-36 showed that the difference was 35±16.24 in SF (p<0.01), 61±20 in RE (p<0.01), 8±16.9 in VT (p<0.05), 38±11.03 in MH (p<0.01), and 47.03±12.74 in GH (p<0.01). A comparison of the data obtained during the first and last visits revealed that there was a decrease of 3.13 points in VAS, 1.6 points in PGA, and 11.63 points in DLQI. Statistically significant improvements were found in the scores of SF, RE, VT, MH, and GH subscales of the SF-36.
Conclusion: The results of this study revealed that IPL was an effective method in the treatment of ETR. Marked reductions were seen in the clinical symptoms after the IPL therapy as evidenced by the VAS and PGA scores. Patient satisfaction was also evidenced by the DLQI and SF-36.

Keywords: Erythematotelangiectatic rosacea, intense pulse light, Dermatology Life Quality Index, visual analog scale, Physician’s Global Assessment Scale, Short Form-36

Eritematöz telenjiektazik rozasede yo?un at?ml? ???k tedavisinin ya?am kalitesine etkisi

Amaç: Yap?lan çal??malar göstermi?tir ki, akne rozase (AR) hastal??? ya?am kalitesini (YK) ciddi bir ?ekilde etkilemektedir. AR tedavisinde farkl? seçenekleri mevcuttur. Bu tedaviler sonras? hastalar?n YK’de iyile?me saptand???na dair literatürde birçok çal??ma mevcuttur. Yo?un at?l?ml? ???kla [intense pulse light (IPL)] AR’nin özellikle eritematöz telenjiektazik rozasenin (ETR) tedavisinde olumlu sonuçlar elde edilmi?tir. Fakat, literatürde IPL’nin ETR’de etkinli?ini gösteren çal??malar olsa da, YK’yi ne kadar olumlu etkiledi?ine dair çal??malar ne uluslararas?, ne de ulusal düzeyde yap?lm??t?r.
Gereç ve Yöntem: Bu çal??mada amac?m?z IPL’nin YK’yi ne kadar olumlu etkiledi?ini belirlemektir. Bu amaçla, çal??amaya ETR tan?s? alm?? ve al?nma kriterlerini kar??layan 30 hasta dahil edilmi?tir. Aç?k-kontrolsüz, prospektif ve kohort bir çal??mada 4 haftada bir olmakla toplam 3 seans IPL tedavisi planlanan hastalara, hem IPL öncesi, hem de IPL tedavisi bitiminden sonra vizüel analog skalas? (VAS), Doktor Global De?erlendirme Skalas? (DGDS), Dermatolojik Ya?am Kalitesi ?ndeksi (DYK?) formu ve K?sa Form-36 (KF-36) ölçeklerinin doldurulmas? planland?.
Bulgular: ?lk seansta ve son seanstaki elde edilen veriler SPSS program? ile de?erlendirilmi?tir ve istatistiksel anlaml? p de?erleri elde edilmi?tir. VAS fark? -3,13±1,46 (p<0,01), DGDS fark? -1,6±0,6 (p<0,01), DYK? fark? ise -11,63±3,13 (p<0,01) olmu?tur. KF-36 formu ise 8 bölümde: Fiziksel fonksiyonellik (FF), fiziksel rol k?s?tl?l??? (FRK), sosyal fonksiyonellik (SF), duygusal rol (DR), bedensel a?r?, canl?l?k (CA), genel ruh sa?l??? (GRS) ve genel sa?l?k (GS) incelenmi?tir. KF-36 formunun istatiksel de?erlendirilmesi zaman?, SF fark? 35±16,24 (p<0,01), DR fark? 61±20 (p<0,01), CA fark? 8±16,9 (p<0,05), GRS fark? 38±11,03 (p<0,01), GS fark? ise 47,03±12,74 (p<0,01) olmu?tur. ?lk ve son vizitlerdeki elde edilen verileri kar??la?t?rd???m?z zaman, VAS’ta 3,13, DGDS’de 1,6, DYK?’de ise 11,63 birim gerileme görülmü?tür. KF-36 formunun SF, DR, CA, GRS ve GS bölümlerinde istatiksel anlaml? iyile?me saptanm??t?r.
Sonuç: Bu çal??man?n sonucunda, IPL’nin ETR tedavisinde etkin bir yöntem oldu?u saptanm??t?r.VAS ve DGDS ölçekleri ile IPL tedavisi sonras? klinik belirtilerde belirgin gerileme görülmü?tür. Ayn? zamanda hasta memnuniyeti, DYK? ve KF-36 formlar? ile ortaya konulmu?tur.

Anahtar Kelimeler: Eritematöz telenjiektazik rozase, yo?un at?l?ml? ???k, Dermatolojik Ya?am Kalitesi ?ndeksi, vizüel analog skalas?, Doktor Global De?erlendirme Skalas?, K?sa Form-36