Turkderm-Turk Arch Dermatol Venereol. 2024; 58(2): 35-41 | DOI: 10.4274/turkderm.galenos.2024.37999

Tekrarlayan aftöz stomatit ile Behçet hastalýðýnda hematolojik parametrelerin karþýlaþtýrýlmasý

Ceylan Avcý, Sevgi Akarsu, Özlem Özbaðçývan
Dokuz Eylül Üniversitesi Týp Fakültesi, Deri ve Zührevi Hastalýklar Ana Bilim Dalý, Ýzmir

Amaç: Hematolojik parametreler çeþitli romatizmal hastalýklarda sistemik enflamasyonu deðerlendirmek için laboratuvar belirteçleri olarak kullanýlmaktadýr. Bu çalýþmanýn amacý; Behçet hastalýðý (BH) kriterlerini yeni karþýlayan hastalar ile rekürren aftöz stomatit (RAS) tanýsý alan hastalar arasýndaki hematolojik parametrelerin farkýný belirlemektir.
Gereç ve Yöntem: Bu kesitsel çalýþmaya yýlda en az üç kez oral ülserasyonlarý ortaya çýkan yeni taný almýþ 20 Behçet hastasý ve 47 RAS tanýlý hasta dahil edildi. Hastalarýn demografik ve klinik özellikleri, tam kan sayýmý, C-reaktif protein (CRP) ve eritrosit sedimentasyon hýzý kaydedildi.
Bulgular: Her iki çalýþma grubunda da hastalarýn cinsiyet, yaþ, oral aftöz ülserasyon süresi ve sýklýðý gibi özellikleri benzerdi (p>0,05). CRP, yeni taný alan BH grubunda RAS grubuna göre anlamlý düzeyde yüksekti (p=0,001). CRP deðerinin 2,7 g/dL’den yüksek, ortalama trombosit hacmi (MCV) deðerinin 7,58 fL’den yüksek ve lenfosit sayýsýnýn 2,85 103/μL’den yüksek olmasýnýn Behçet hastalarýný RAS hastalarýndan ayýrmada belirteç olarak belirlendi [sýrasýyla; olasýlýk oraný (OO): 12,76 (%95 güven aralýðý (GA): 2,86-56,88), OO: 5,61 (%95 GA: 1,11-28,42), OO: 15,24 (%95 GA: 1,77-131,31)].
Sonuç: Yüksek CRP, MCV ve lenfosit sayýsý, RAS hastalarýndan ziyade yeni taný almýþ Behçet hastalarý ile iliþkiliydi. Bu bulgularýn doðrulanmasý için saðlýklý kontrol grubuyla daha geniþ hasta sayýlarýný içeren prospektif çalýþmalara ihtiyaç vardýr.

Anahtar Kelimeler: Behçet hastalýðý, rekürren aftöz stomatit, kan hücresi sayýmý

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Comparison of the hematological parameters of recurrent aphthous stomatitis and Behçet’s disease

Ceylan Avcý, Sevgi Akarsu, Özlem Özbaðçývan
Dokuz Eylül University Faculty of Medicine, Department of Dermatology, Ýzmir, Türkiye

Background and Design: Hematological parameters have been used as laboratory markers to evaluate the systemic inflammation in several rheumatic disease. The aim of this study is to determine the difference of hematological parameters between the patients who have been just fulfilled the Behçet’s disease (BD) criteria and patients with recurrent aphthous stomatitis (RAS).
Materials and Methods: Twenty patients with newly diagnosed BD and 47 patients with RAS whose oral ulcerations appeared at least three times a year were enrolled in this cross-sectional study. Demographic and clinical characteristics of patients, complete blood count, C-reactive protein (CRP) and erythrocyte sedimentation rate were recorded.
Results: Patients’ characteristics including gender, age, duration, and frequency of oral aphthous ulcerations in both study groups were comparable (p>0.05). CRP was significantly higher in newly diagnosed BD group when compared to the RAS group (p=0.001). CRP value higher than 2.7 g/dL, mean platelet volume (MPV) value higher than 7.58 fL and lymphocyte count higher than 2.85 103/μL were found to be the markers for distinguishing patients with BD from patients with RAS [odds ratio (OR): 12.76 (95% confidence interval (CI): 2.86-56.88), OR: 5.61 (95% CI: 1.11-28.42), OR: 15.24 (95% CI: 1.77-131.31), respectively].
Conclusion: The elevated CRP, MPV and lymphocyte count were associated with patients with newly diagnosed BD rather than patients with RAS. Further large prospective studies with the healthy control group are needed to confirm these findings.

Keywords: Behçet disease, recurrent aphthous stomatitis, blood cell count

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ATIF KOPYALA