Turkderm-Turk Arch Dermatol Venereol. 2023; 57(2): 38-42 | DOI: 10.4274/turkderm.galenos.2023.50146

Rozaseada yeni enflamatuvar belirteçler olan monosit/ yüksek yoðunluklu lipoprotein kolesterol, nötrofil/ yüksek yoðunluklu lipoprotein kolesterol, lenfosit/yüksek yoðunluklu lipoprotein kolesterol oranlarýnýn araþtýrýlmasý

Bülent Nuri Kalaycý
Malatya Turgut Özal Üniversitesi Týp Fakültesi, Dermatoloji Anabilim Dalý, Malatya, Türkiye

Amaç: Rozasea kronik enflamatuvar bir deri hastalýðýdýr. Monosit/yüksek yoðunluklu lipoprotein (HDL) kolesterol oraný (MHR), nötrofil/HDL kolesterol oraný (NHR) ve lenfosit/HDL kolesterol oraný (LHR) enflamatuvar hastalýklar ile iliþkili bulunan yeni enflamatuvar parametrelerdir. Çalýþmamýzda rozasealý hastalarda ve saðlýklý kontrollerde MHR, NHR ve LHR parametrelerin araþtýrýlmasý ve hastalýk þiddeti ile iliþkisinin belirlenmesi amaçlandý.
Gereç ve Yöntem: Hastanemize baþvuran rozasea tanýsý almýþ 82 hasta ve 82 saðlýklý kontrol retrospektif olarak çalýþmaya alýndý. Hasta ve saðlýklý kontroller için MHR, NHR, LHR deðerleri hesaplandý. Hastalýk þiddetinin ölçümünde rozasea klinik þiddet skoru kullanýldý. Hastalar klinik alt tiplerine, hastalýk þiddetine ve Demodeks varlýðýna göre gruplara ayrýldý.
Bulgular: Çalýþmaya alýnan 82 hastanýn 62’si (%75,6) kadýn, 20’si (%24,4) erkek ve yaþ ortalamalarý 41,95±1,2 (22-65,43), kontrol grubunun 64’ü (%78) kadýn,18’i (%22) erkek ve yaþ ortalamalarý 41,8±0,9 (27-55,42) idi (p>0,05). Ortalama MHR deðeri rozasealý hastalarda 0,01±0,005 iken kontrol grubunda 0,009±0,003 idi (p=0,01). Ortalama NHR deðeri rozasealý hastalarda 0,10±0,05; kontrol grubunda 0,08±0,02 idi (p=0,04). Ortalama LHR deðeri hasta grubunda 0,05±0,02; kontrol grubunda 0,04±0,01 olarak bulundu (p>0,05). Rozasea klinik gruplarý, Demodeks gruplarý ve hastalýk þiddeti ile MHR, NHR, LHR ortalama deðerleri arasýnda anlamlý bir fark saptanmadý (p>0,05). Alýcý iþletim karakteristiði analizinde MHR için kesme deðeri 0,009 (%67 sensitivite ve %60 spesifite ile) ve NHR için kesme deðeri 0,08 (%64 sensitivite ve %60 spesifite ile) olarak hesaplandý.
Sonuç: Rozasealý hastalarda sistemik enflamasyonun göstergesi olarak MHR ve NHR parametrelerinin kullanýlabileceðini düþünmekteyiz.

Anahtar Kelimeler: Monosit/HDL kolesterol, nötrofil/HDL kolesterol, lenfosit/HDL kolesterol, rozasea

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Monocyte/high-density lipoprotein cholesterol, neutrophil/high-density lipoprotein cholesterol, and lymphocyte/high-density lipoprotein cholesterol ratios as new inflammatory markers in rosacea

Bülent Nuri Kalaycý
Malatya Turgut Özal University Faculty of Medicine, Department of Dermatology, Malatya, Türkiye

Background and Design: Rosacea is a chronic inflammatory skin disease. The monocyte/high-density lipoprotein (HDL) cholesterol ratio (MHR), neutrophil/HDL cholesterol ratio (NHR), and lymphocyte/HDL cholesterol ratio (LHR) are new inflammatory parameters associated with inflammatory diseases. This study aimed to compare MHR, NHR, and LHR between patients with rosacea and healthy controls and determine the relationship of these parameters with disease severity.
Materials and Methods: The study retrospectively included 82 patients who presented to our hospital with rosacea and 82 healthy controls. The MHR, NHR, and LHR of the patient and control groups were calculated. Patients were divided into groups according to the clinical subtypes, disease severity, and presence of Demodex mites.
Results: Of the 82 patients included in the study, 62 (75.6%) were female and 20 (24.4%) were male, and their mean age was 41.95±1.2 (22-65.43) years. The mean MHR values of the rosacea and control groups were 0.01±0.005 and 0.009±0.003, respectively, and the difference was statistically significant (p=0.01). The mean NHR values of the rosacea and control groups were 0.10±0.05 and 0.08±0.02, respectively, and the difference was statistically significant (p=0.04). The mean LHR values of the rosacea and control groups were 0.05±0.02 and 0.04±0.01, respectively, indicating no statistically significant difference (p>0.05). For the prediction of patients with rosacea, the cut-off MHR was calculated as 0.009 (67% sensitivity and 60% specificity) and that of NHR was 0.08 (64% sensitivity and 60% specificity).
Conclusion: The results reveal that MHR and NHR parameters can be used as indicators of systemic inflammation in patients with rosacea.

Keywords: Monocyte/HDL cholesterol, neutrophil/HDL cholesterol, lymphocyte/HDL cholesterol, rosacea

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