Turkderm-Turk Arch Dermatol Venereol. 2022; 56(1): 61-66 | DOI: 10.4274/turkderm.galenos.2022.06337

İnterkökin-23 inhibitörleri

Esra Adışen
Gazi Üniversitesi Tıp Fakültesi, Deri ve Zührevi Hastalıklar Anabilim Dalı, Ankara

Sistemik tedavi planlanan orta ve şiddetli plak tip psoriasisli erişkin hastalarda interlökin-23 (IL-23) inhibisyonu yoluyla etki eden ajanlardan FDA onayı alanlar guselkumab, tildrakizumab ve risankizumabtır. IL-23 inhibitörleri ile tedavi edilen psoriasisli olgularda tedaviye yanıt 12 haftalık tedavi sonrası değerlendirilmelidir. Kısmi yanıt veren hastalarda doz artışı planlanabilir ya da tedaviye topikal kortikosteroidler, D vitamini analogları, metotreksat, fototerapi (UVB) eklenilebilir.

Anahtar Kelimeler: IL-23 inhibitörü, guselkumab, tildrakizumab, risankizumab

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Interleukin-23 Inhibitors

Esra Adışen
Gazi University Faculty of Medicine, Department of Dermatology and Venereology, Ankara, Turkey

For adult patients with moderate to severe plaque psoriasis scheduled for systemic therapy, FDA-approved agents that act via interleukin-23 (IL-23) inhibition are guselkumab, tildrakizumab, and risankizumab. Response to treatment should be evaluated after a 12-week treatment period in psoriasis patients being treated with IL-23 inhibitors. In patients with partial response, dose increase may be planned, or topical corticosteroids, vitamin D analogs, methotrexate, or phototherapy (UVB) may be added to the treatment.

Keywords: IL-23 inhibitor, guselkumab, tildrakizumab, risankizumab

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