Otoimm�n B�ll�z Hastal�klar�n Etyopatogenezi

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Otoimm�n B�ll�z Hastal�klar�n Etyopatogenezi [Turkderm-Turk Arch Dermatol Venereol]

Turkderm-Turk Arch Dermatol Venereol. 2011; 45(1): 8-15 | DOI: 10.4274/turkderm.45.s3

Otoimm�n B�ll�z Hastal�klar�n Etyopatogenezi

�ebnem Aktan
Dokuz Eyl�l �niversitesi T�p Fak�ltesi Deri Ve Z�hrevi Hastal�klar Anabilim Dal�, �zmir

Otoimm�n b�ll�z hastal�klar, epidermis i�inde veya epidermisin dermise ba�lant�s�nda i�lev g�ren hedef antijenlere kar�� geli�mi� patojenik antikorlarla karakterize deri ve mukozalar� tutan nadir g�r�len tablolard�r. Son y�llarda bu hastal�klar�n patogenezi ileri tetkikler kullan�larak yap�lan �al��malarla yo�un olarak ara�t�r�lm��t�r. Bu derlemede temel otoimm�n b�ll�z hastal�klardan pemfigus, b�ll�z pemfigoid, anti-p200 pemfigoid, sikatrisyel pemfigoid, pemfigoid gestasyones, dermatitis herpetiformis, lineer IgA hastal�� ve edinsel epidermolizis b�llozan�n etyopatogenezi �zerinde durulacakt�r.

Anahtar Kelimeler: Otoimm�n b�ll�z hastal�k, pemfigus, b�ll�z pemfigoid, anti-p200 pemfigoid, sikatrisyel pemfigoid, pemfigoid gestasyones, dermatitis herpetiformis, lineer IgA hastal��, edinsel epidermolizis b�lloza

The Etiopathogenesis of Autoimmune Bullous Diseases

�ebnem Aktan
Dokuz Eyl�l �niversitesi T�p Fak�ltesi Deri Ve Z�hrevi Hastal�klar Anabilim Dal�, �zmir, T�rkiye

Autoimmune bullous diseases are rare disorders affecting skin and mucous membranes which are mediated by pathogenic autoantibodies against target antigens whose function is adhesion within the epidermis or adhesion of epidermis to dermis. The pathogenesis of these disorders has been extensively investigated with advanced techniques in recent years. This review focuses on the etiopathogenesis of main autoimmune bullous disorders including pemphigus, bullous pemphigoid, anti-p200 pemphigoid, cicatricial pemphigoid, pemphigoid gestationis, dermatitis herpetiformis, linear IgA bullous dermatosis and
epidermolysis bullosa acquisita.

Keywords: Autoimmune disease, skin diseases, vesiculobullous, pemphigus, pemphigoid, bullous, benign mucous membrane, laminin gamma 1, pemphigoid gestationis, dermatitis herpetiformis, immunoglobulin A, dermatosis, epidermolysis bullosa acquisita

Sorumlu Yazar: �ebnem Aktan
Makale Dili: T�rk�e

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