Multinükleer hücreli anjiyohistiyositom: Altý olgu sunumu

Multinükleer hücreli anjiyohistiyositom (MNAH) genellikle yaþlý kadýnlarýn alt ekstremite ve el dorsumlarýnda görülen benign fibrohistiyositik ve vasküler bir proliferasyondur. Üçü erkek üçü kadýn altý hasta asemptomatik multipl ve soliter papüller nedeniyle polikliniðimize baþvurdu. Histopatolojik incelemelerinde dermisde vasküler proliferasyon, perivasküler lenfoplazmositik ve fibrohistiyositik hücre infiltrasyonu ve multinükleer stromal hücreler gözlendi. Klinik ve patolojik bulgularla MNAH tanýsý konuldu. MNAH yavaþ ancak progresif gidiþli, tedavi gerektirmeyen bir antitedir. Ancak klinisyen ve patologlar tarafýndan bilinmediði için tanýsý gecikmekte, yanlýþ tanýlar nedeniyle gereksiz giriþim ve tedavilere neden olabilmektedir. Kutanöz vasküler proliferasyonlarýn ayýrýcý tanýsýnda mutlaka akla gelmelidir.

Multinucleate cell angiohistiocytoma: A report of six cases

Multinucleate cell angiohistiocytoma (MCAH) is a benign fibrohistiocytic and vascular proliferation that it is seen on the dorsae of the hands or lower extremities in elderly women. Six cases, three males and three females, who had multiple or solitary asymptomatic skin lesions were admitted to our clinic. Histopathological examinations revealed vascular proliferation, perivascular lymphoplasmacytic, fibrohistiocytic infiltration and multinucleated stromal cells in the dermis. Based on the clinical and pathological findings, the diagnosis was MCAH. MCAH shows a slow but progressive course. MCAH is an entity that is not requiring any treatment. However, it is not well known by clinicians or pathologists and misdiagnosis may lead to unnecessary investigations and therapy. It should certainly be taken into consideration during differential diagnosis of cutaneous vascular proliferations.