Zorlu Oral Hastalýklarda Güncel Tedavi: Rekürren Oral Aftozis

Rekürren oral aftozis (ROA) oral ülserasyonun en sýk sebebidir. Etyolojisi henüz belli olmamakla birlikte, lokal ve sistemik koþullar ile genetik, immünolojik ve mikrobial faktörlerin hepsi patogenezde rol oynayabilir. Tedavide temel amaçlar; aðrý kontrolü, iyileþmeyi hýzlandýrmak ve tekrarlarý önlemektir. Tedavinin temelini anestezik, antiseptik, anti-inflamatuar, tetrasiklin, sukralfat veya steroidlerle topikal tedavi oluþturur. Topikal tedavilerle yeterli yanýt alýnamadýðý veya inatçý majör ülserlerde sistemik tedaviler gerekir. Sistemik tedavide kullanýlan baþlýca ajanlar; steroid, kolþisin, pentoksifilin, talidomid, dapson, azatioprin ve metotreksattýr. Son yýllarda anti-TNF-alfa biyolojik ajanlar da tedavide kullanýlmaya baþlanmýþ ve etkili bulunmuþtur.

Current Treatment Options in Challenging Oral Diseases: Recurrent Oral Aphthosis

Recurrent oral aphthosis (ROA) is the most common cause of oral ulceration. The etiology is still not well understood, although local and systemic conditions, genetic, immunological and microbial factors play a role in the pathogenesis. The aim of the treatment is to control pain, accelerate the healing and prevent recurrences. The mainstay of treatment is topical therapy with anesthetics, antiseptics, anti-inflammatories, tetracyclines, sucralfate or steroids. Nevertheless, topical treatments may not always adequate or if there are major ulcers or persistent ulcers, systemic therapy is required. The main agents used in the treatment are systemic steroids, colchicine, pentoxifylline, thalidomide, dapsone, azathioprine, and methotrexate. In recent years, anti-TNF-alpha biological agents had been used for therapy and found to be effective.