Turkderm-Turk Arch Dermatol Venereol. 2013; 47(2): 111-118 | DOI: 10.4274/turkderm.47.s19

Selim deri tümörleri ve sistemik malinite iliþkisi

K. Didem Yazganoðlu, Can Baykal
Ýstanbul Üniversitesi Ýstanbul Týp Fakültesi, Deri Ve Zührevi Hastalýklar Anabilim Dalý, Ýstanbul, Türkiye

Derinin karmaþýk histolojik görüntüsü ile iliþkili olarak çok sayýda selim deri tümörü tipi vardýr. Bunlardan az bir bölümü sistemik maliniteler ile iliþki gösterebilir. Bu makalede sistemik maliniteler ile iliþkisi iyi bilinen veya tartýþmalý olan selim deri tümörlerinden bahsedilecektir. Bahsi geçen tümörler ve iliþkili olduðu durumlar þunlardýr: seboreik keratoz/ Leser-Trélat belirtisi, lentigo simpleks/ Peutz Jeghers ve Carney sendromu, yað bezi tümörleri/Muir-Torre sendromu, fibrofoliküloma- trikodiskoma/ Birt-Hogg-Dubé sendromu, trikoepitelyom-silindrom-spiradenom/ Brooke- Spiegler sendromu, leiomyom/ multipl kutane ve uterin leiyomiyomatozis sendromu, glomeruloid hemanjiyom/ POEMS sendromu, venöz malformasyon/ Maffucci sendromu, mukozal nörom/ multipl endokrin neoplazi tip 2B, jüvenil ksantogranülom/ jüvenil kronik miyeloid lösemi. Deri tümörleri ve iliþkili olduðu belirtilerin veya sendromlarýn sistemik malinite riskinin bilinmesi, malinitelerin erken tanýsý açýsýndan önem taþýr.

Anahtar Kelimeler: Selim deri tümörü, malinite, paraneoplazi, Leser-Trélat belirtisi, Muir-Torre sendromu, Birt-Hogg-Dubé sendromu, Reed sendromu, multipl mukozal nörom

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Benign skin tumors in association with systemic malignancy

K. Didem Yazganoðlu, Can Baykal
Department Of Skin And Venereal Diseases, Istanbul University Istanbul Faculty Of Medicine, Istanbul, Turkey

There are various types of benign skin tumors in association with the complex nature of the skin. A minor part of them may be associated with visceral malignancies. This review focuses on the benign skin tumors that are described to have well-known associations with systemic malignancies or those with controversial associations. These tumors and the associated conditions are as follows: seborrheic keratosis/ Leser-Trélat sign, lentigo simplex/Peutz Jeghers and Carney syndrome, sebaceous tumors/ Muir-Torre syndrome, fibrofolliculoma- trichodiskoma/ Birt-Hogg-Dubé syndrome, trichoepitheliomacylindroma- spiradenoma/ Brooke-Spiegler syndrome, leiomyoma/multiple cutaneous and uterin leiomyomatosis syndrome, glomeruloid hemangioma/ POEMS syndrome, venous malformation/ Maffucci syndrome, mucosal neuroma/ multiple endocrine neoplasia type 2B, juvenile xanthogranuloma/ juvenile chronic myeloid leukemia. It is important to know the skin tumors related with visceral malignancies in part of a syndrome or in association with a sign as this may yield an earlier recognition of these malignancies.

Keywords: Benign skin tumor, malignancy, paraneoplasia, sign of Leser-Trélat, Muir-Torre syndrome, Birt-Hogg-Dubé syndrome, Reed syndrome, multiple mucozal neuroma

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ATIF KOPYALA