Psoriasis ve Komorbiditeler

Psoriasis genel populasyonda %1-3 oranýnda görülen, immün aracýlý mekanizmalarla geliþtiði için Immune Mediated Inflammatory Disease (IMID) olarak tanýmlanan kronik inflamatuvar hastalýklardan biridir. Son yýllarda, psoriasisdeki kronik inflamasyonun metabolik ve vasküler bozukluklarýn geliþimine neden olduðu öne sürülmekte ve çalýþmalar psoriasise eþlik eden komorbiditeler ve mekanizmalarý üzerine yoðunlaþmaktadýr. Psoriasis ile iliþkili komorbiditeler arasýnda olan psoriatik artrit, Crohn hastalýðý, püstüler hastalýklar, metabolik sendrom, malignansiler, tedavilerle iliþkili komorbiditeler, akciðer hastalýklarý, sigara, enfeksiyonlar, yaþam kalitesine etki ve depresyon ile alkol bulunmaktadýr.

Psoriasis and Co-morbidities

Psoriasis is a chronic inflammatory skin disorder affecting about 1-3% of general population, is defined among Immune Mediated Inflammatory Disease (IMID) since it develops with immune associated mechanisms. It has been proposed that the chronic inflammation in psoriasis have role in the development of metabolic and vascular disorders related with psoriasis and recent studies have focused on the psoriasis associating comorbidities and their mechanisms. Psoriasis comorbidities include psoriatic arthritis, Crohn’s disease, pustular disorders, metabolic syndrome, malignities, comorbidities related to treatments, pulmonary diseases, smoking, infections, impact on life quality and depression, and alcohol.