Background and Design: This study aimed to investigate any relationship between an emerging attention deficit in patients with acne vulgaris and have reached cumulative doses under isotretinoin treatment. Materials and Methods: A total of 100 patients (aged: 16-40 years) with acne vulgaris who have reached cumulative doses under isotretinoin medication for over a period of 6 months were included in the study. Using the Stroop Color and Word Test (SCWT), attention was assessed in the patients at the beginning and 3rd and 6th month of the treatment. Results: A repeated measures ANOVA analysis was performed to determine whether there was any change in the SCWT results over time after the first dose and 3rd and 6th month of the treatment. The changes in all SCWT results were statistically significant with respect to time. The time required for each task assessed by means of the SCWT was found to be significantly reduced over time. Conclusion: After evaluating the results of the SCWT performed at the beginning and 3rd and 6th month of the treatment, it was concluded that the treatment with the cumulative doses of isotretinoin was not significantly associated with any emerging attention deficit symptoms or signs in patients with acne vulgaris. It is possible that the patients were trained during the SCWT with the repeated performances in the study, which may have resulted a significant decrease in the test duration. This prospective study suggests that there is no casual relationship between the use of isotretinoin and attention deficit in patients with acne vulgaris

Background and Design: To examine the effectiveness of Ýstanbul Occupational Diseases Hospital on employer attitude and worker’s health in terms of occupational skin diseases and also to investigate the prognosis of occupational skin diseases. Materials and Methods: In 2014-2015, 56 patients who were admitted to Ýstanbul Occupational Disease Hospital and diagnosed with occupational dermatosis were included in the study. The examination findings, diagnoses, disease involvement areas and the consultation data of patients who were replaced, not made and dismissed, and professional groups files were obtained and analyzed retrospectively during the initial and subsequent checkups of the patients. Results: Of the 56 patients with a mean age of 36, 9 (16.1%) were female and 47 (83.9%) were male. The most common occupational dermatosis was contact dermatitis. Of these, 29 (51.8%) were evaluated as irritants and 22 (39.3%) as allergic contact dermatitis. Allergic contact urticaria in 3 patients, perniosis in one patient and systemic sclerosis in one patient were detected. The most common locations of the dermatoses were the hands. Irritant dermatitis was the most common in metal and allergic dermatitis was the most common in textile workers. 32 (57.1%) patients underwent a departmental changewhile 24 (42.9%) patients did not. While 14 (58.3%) patients were dismissed, 10 (41.7%) continued to work in the same department. Of the 32 patients who underwent departmental changes, 24 (75%) were monitored for improvement, while 8 (25%) were not. Recovery was observed in 32 (71.2%) of the 46 patients with environment change and it was statistically significant (p=0.001). No recurrence was observed in any of the patients who fully recovered during their the six-month follow-up. Conclusion: Environment change improvement monitoring in 32 of 46 workers (71.2%) shows the importance of environment change in occupational dermatoses and the contribution of our hospital to worker health. The fact that 32 (57.1%) patients underwent department changes suggests that our hospital is effective on employers

Background and Design: The most important avoidable risk factor for skin cancer is ultraviolet light exposure. The aim of this study is to evaluate the frequency and the effect of counseling on sun protection behaviors and early detection of skin cancer. Materials and Methods: Five hundred individuals aged 45-75 years participated in this cross-sectional survey between February 6th and March 07th of 2019. Participants were directed to filled out a questionnaire to understand their sun protection behaviors and learn whether they receive counseling on sun protection and early detection of skin cancer. Results: Out of the 500 subjects, 283 (56.6%) were female and 217 (43.4%) were male. The mean age was 56.65±9.24 years (45-75 years). Two hundred and thirty-four (46.8%) respondents reported having skin-cancer risk factors. The rates of counseling on sun protection and behavior of sun protection were 16% and 39.4%, respectively. Sun protection counseling was significantly associated with self-reported skincancer risk factors and being a female (p<0.001; p=0.048, respectively). The rate of counseling on early detection of skin cancer was low (skin selfexamination: 12%; moles monitoring: 11.8%; annual checkup: 13.2%). The counseling on sun protection and early detection of skin cancer were significantly associated with behaviors of sun protection and early detection of skin cancer (p<0.001; p<0.001, respectively). The older age had a negative effect on the counseling and behaviors (p=0.047; p=0.005, respectively), however, high level of education had a positive effect (p=0.024; p<0.001). Conclusion: Counseling by healthcare professionals on primary and secondary preventions for the middle-aged and older people seems to be insufficient. Further studies on this issue may be beneficial on prevention and early detection of skin cancer.

Background and Design: Psoriasis is a chronic papulosquamous disease where histologically epidermal hyperproliferation and infiltration involving natural killer cells and cytotoxic T-cells are observed. These cells have been shown to carry cytolytic molecules containing high amount of perforin, granzyme B and granulysin (GNLY). The roles of these molecules in the pathogenesis of psoriasis are still disputed, with serum GNLY and cathepsin-l (CL) levels thought to be associated with cellular immunity. In this study, we investigated the relationship between the severity and duration of psoriasis and the levels of CL and GNLY. Materials and Methods: Prospective and randomized study of 40 patients (23 males, 17 females) with psoriasis who admitted to hospital between December 2014 and August 2015, and 40 age and sex-matched healthy controls (23 males, 17 females) were investigated. CL and GNLY serum levels were measured by ELISA method. Results: There was no significant differences in GNLY and CL levels between psoriasis patients and the control group (p=0.243 and p=0.606). There was also no statistically significant difference between psoriasis patients with low Psoriasis Area Severity Index (PASI) (≤10) and those with high PASI (>10) (p=0.86 and p=0.61) score. Conclusion: There are studies that have shown GNLY and CL in the psoriazis are important markers for disease pathogenesis. However, according to the results of this study, CL and GNLY levels are not sufficient markers to indicate the level of cellular immunity and disease severity in psoriasis. Future studies are needed on this subject with a wider range of patients.

Although the efficacy of topical sirolimus for facial angiofibromas of tuberosclerosis is now appreciated, drug-induced irrritation complicates the use of the concentration recommended in the literature as 1%. Adjuvant vascular or ablative laser applications may be preferred in adult patients for a variety of purposes, such as treatment of large lesions that tend to be resistant to topical treatment, reduction of topical product concentration and rapid response generation. Herein, we aimed to share the 2-year follow up result of a tuberoussclerosis case where angiofibromas were observed on the chin, malar regions and nose. We combined the full-field erbium-yttrium aluminium garnet laser application with topical sirolimus 0.25% cream on the second month of treatment.

Reactive perforating collagenosis (RPC) is characterized by hyperkeratotic papules and histopathologically transepidermal elimination of structural altered collagen fibers. It is often associated with diabetes mellitus and renal failure. Superficial skin trauma is thought to play a role in triggering the disease. In this article, we present a rare case of a 59-year-old woman with complaint of itching and scabs for 2 months. The patient diagnosed with scabies and RPC treated with 5% permethrin. After scabies treatment, the symptoms and clinical findings of RPC were successfully checked.

Perforating dermatoses are a group of diseases characterized by transepidermal elimination of dermal components such as collagen, elastin and fibrin. Perforating dermatoses primarily include four main forms: reactive perforating collagenosis, elastosis perforans serpiginosa, perforating folliculitis and acquired perforating dermatosis. There is limited data about perforating dermatoses in the literature. Because of their rare appearance, they can be easily misdiagnosed. Acquired perforating dermatosis is a systemic disease such as diabetes and chronic renal failure; and it should be considered in case of pruritic papulonodules and giant plaques with central crater in a patient. In addition to the treatment of underlying disease in the first stage; narrow band ultraviolet B (nbUVB) is evaluated to be effective in these cases. Based on its rare occasions, we submit a giant variant of acquired perforating dermatosis with a collagen fiber predominant elimination pattern, which is treated with nbUVB.

Lichen planus pigmentosus (LPP) is an inflammatory dermatosis with an unknown etiology characterized by dark brown-black macules, papules and patches. LPP is considered as a rare variant of lichen planus (LP), but it differs from the LP by the absence of nail and oral area involvement and pruritus. LPP is most common on sun-exposed areas and less frequently seen in the axilla, inguinal or submammary regions. In the literature, very few cases have been reported to be associated with LPP. Herein, we reported two cases with LPP accompanied by ankylosing spondylitis and high levels of adrenocorticotropic hormone along with diabetes mellitus.